Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

Immunotherapy that harnesses the power of the immune system to eliminate malignant cells
has offered an effective approach for cancer treatment. However, limited patient response …

Immunotherapy has offered new treatment options for cancer; however, the therapeutic
benefits are often modest and desired to be improved. A semiconducting polymer …

Imidazoquinoline derivatives (IMDs) and related compounds function as synthetic agonists
of Toll-like receptors 7 and 8 (TLR7/8) and one is FDA approved for topical antiviral and skin …

Immunotherapy holds great promise for the treatment of aggressive and metastatic cancers;
however, currently available immunotherapeutics, such as immune checkpoint blockade …

Photothermal therapy (PTT) applies photothermal agents to convert light into heat to
eliminate primary tumors and induce subsequent immune responses, but the ineffectiveness …

Due to the intrinsic weak immunogenicity of tumor cells and the quantitatively and
functionally different populations of immune cells, immunosuppression has become the …

Tumor-associated macrophages (TAM) interact with cancer and stromal cells and are
integral to sustaining many cancer-promoting features. Therapeutic manipulation of TAM …

Immunotherapy has revolutionized the contemporary oncology landscape, with durable
responses possible across a range of cancer types. However, the majority of cancer patients …

ABSTRACT Resiquimod (R848) and motolimod (VTX-2337) are second-generation
experimental derivatives of imiquimod, an imidazoquinoline with immunostimulatory …