The reconstruction of musculoskeletal defects is a constant challenge for orthopaedic
surgeons. Musculoskeletal injuries such as fractures, chondral lesions, infections and tumor …

Mechanical forces influence homeostasis in virtually every tissue [1, 2]. Tendon, constantly
exposed to variable mechanical force, is an excellent model in which to study the conversion …

Rotator cuff tears are common soft-tissue injuries that often require surgical treatment. Initial
efforts to better tendon healing centered on improving the strength of the repair. More recent …

Objective: Acellular human tendons are a candidate scaffold for tissue engineering flexor
tendons of the hand. This study compared acellularization methods and their compatibility …

Tendon injuries range from acute traumatic ruptures and lacerations to chronic overuse
injuries, such as tendinosis. Even with improved nonsurgical, surgical, and rehabilitation …

Our long-term objective is to enhance tendon repair by delivering cells on natural biologic
scaffolds to the repair site. Clinical outcomes may be improved by first preconditioning these …

Tendons have poor spontaneous regenerative capabilities, and complete regeneration is
never achieved despite intensive remodeling. In this in vitro study, we characterized two …

Tendon rupture is a common injury. Inadequate endogenous repair often leaves patients
symptomatic, with tendons susceptible to re-rupture. Administration of certain growth factors …

Dynamic mechanical culture systems are a widely studied approach for improving the
functional mechanical properties of tissue engineering constructs intended for loading …

Introduction Tendons establish specific connections between muscles and the skeleton by
transferring contraction forces from skeletal muscle to bone thereby allowing body …