The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …

Vascular calcification is highly prevalent and, when present, is associated with major
adverse cardiovascular events. Vascular smooth muscle cells play an integral role in …

Pseudoxanthoma elasticum (PXE) is a genetic metabolic disease with autosomal recessive
inheritance caused by mutations in the ABCC6 gene. The lack of functional ABCC6 protein …

The aorta is a blood vessel that provides a low-resistance path for blood flow directed from
the heart to peripheral organs and tissues. However, the aorta has another central …

The physicochemical deposition of calcium-phosphate in the arterial wall is prevented by
calcification inhibitors. Studies in cohorts of patients with rare genetic diseases have shed …

Various disorders including pseudoxanthoma elasticum (PXE) and generalized arterial
calcification of infancy (GACI), which are caused by inactivating mutations in ABCC 6 and …

Sex differences in cardiovascular disease (CVD), including aortic stenosis, atherosclerosis
and cardiovascular calcification, are well documented. High levels of testosterone, the …

Pathological (ectopic) mineralization of soft tissues occurs during aging, in several common
conditions such as diabetes, hypercholesterolemia, and renal failure and in certain genetic …

Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality.
Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting …