Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound
hemoproteins that are responsible for the metabolism of a wide variety of clinically …

Bone is a tissue with constant remodeling, where osteoblasts form and osteoclasts degrade
bone. Both cell types are highly specialized in their function and both form from precursors …

Arthropod herbivores cause dramatic crop losses, and frequent pesticide use has led to
widespread resistance in numerous species. One such species, the two-spotted spider mite …

The systematic study of drug metabolism began in the 19th Century, but most of what we
know now has been learned in the last 50 years. Drug metabolism continues to play a …

The term 'differences of sex development'(DSD) refers to a group of congenital conditions
that are associated with atypical development of chromosomal, gonadal, or anatomical sex …

Disorders of adrenal steroidogenesis comprise autosomal recessive conditions affecting
steroidogenic enzymes of the adrenal cortex. Those are located within the 3 major branches …

NADPH cytochrome P450 oxidoreductase (CPR) is the obligatory electron supplier that
sustains the activity of microsomal cytochrome P450 (CYP) enzymes. The variant nature of …

Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders due to
pathogenic variants in genes encoding enzymes and cofactors involved in adrenal …

Congenital adrenal hyperplasia includes autosomal recessive conditions that affect the
adrenal cortex steroidogenic enzymes (cholesterol side-chain cleavage enzyme; 3β …

Ferroptosis has been described recently as an iron-dependent cell death driven by
peroxidation of membrane lipids. It is involved in the pathogenesis of a number of diverse …