Congenital adrenal hyperplasia (CAH) is a family of autosomal recessive disorders in which
there is a deficiency of one of the enzymes necessary for cortisol synthesis. An abnormality …

Cytochrome P450 oxidoreductase (POR) is the redox partner of steroid and drug-
metabolizing cytochromes P450 located in the endoplasmic reticulum. Mutations in POR …

Cytochrome P450 monooxygenases (CYPs) are the most important enzymes responsible for
the structural diversity of triterpenoids (Xu et al. 2004). CYPs are classified based on their …

Introduction and objectives: Type 2 diabetes mellitus (T2DM) is associated with a great risk
of developing neurological comorbidities, which are, at least partly, responsible for the …

Objectives 46, XY differences/disorders of sex development (DSD) involve an abnormal
gonadal and/or genital (external and/or internal) development caused by lack or incomplete …

Triterpenoids are one of the most diverse groups of plantspecialized metabolites, with more
than 20,000 compounds known to exist in nature (Oldfield and Lin, 2012). One of the …

Triterpenoids are plant specialized metabolites with various pharmacological activities. They
are widely distributed in higher plants, such as legumes. Because of their low accumulation …

Cytochrome P450 oxidoreductase deficiency (PORD) is a rare form of congenital adrenal
hyperplasia that can manifest with skeletal malformations, ambiguous genitalia, and …

Genetic forms of primary adrenal insufficiency (AI) present clinical heterogeneity, variable
modes of inheritance, and association with several clinical pictures. Congenital adrenal …

Cytochrome P450 oxidoreductase (POR) is the redox partner of steroid and
drugmetabolizing cytochromes P450 located in the endoplasmic reticulum. Mutations in …