Mitochondria control cellular fate by various mechanisms and are key drivers of cellular
metabolism. Although the main function of mitochondria is energy production, they are also …

The overall success of human reproduction, either spontaneously or after IVF, is highly
dependent upon maternal age. The main reasons for age-related infertility include reduced …

For electrons to continuously enter and flow through the mitochondrial electron transport
chain (ETC), they must ultimately land on a terminal electron acceptor (TEA), which is known …

The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Mitochondria, fundamental organelles in cell metabolism, and ATP synthesis are
responsible for generating reactive oxygen species (ROS), calcium homeostasis, and cell …

The excessive amount of zeros in single-cell RNA-seq (scRNA-seq) data includes 'real'zeros
due to the on-off nature of gene transcription in single cells and 'dropout'zeros due to …

The role of mitochondria as a nexus of developmental regulation in mammalian oogenesis
and early embryogenesis is emerging from basic research in model species and from …

It is well known that female reproduction ability decreases during the forth decade of life due
to age-related changes in oocyte quality and quantity; although the number of women trying …

At fertilization, the gametes endow the embryo with a genomic blueprint, the integrity of
which is affected by the age and environmental exposures of both parents. Recent studies …