Insulin resistance and chronic cardiovascular inflammatory syndrome

JM Fernández-Real, W Ricart - Endocrine reviews, 2003 - academic.oup.com
Insulin resistance is increasingly recognized as a chronic, low-level, inflammatory state.
Hyperinsulinemia and insulin action were initially proposed as the common preceding …

[HTML][HTML] The multifaceted impact of complement on atherosclerosis

MG Kiss, CJ Binder - Atherosclerosis, 2022 - Elsevier
As one of the cornerstones of innate immunity, the complement system has long been
implicated in the pathogenesis of atherosclerosis. Growing evidence demonstrates the …

The immune system and hypertension

MV Singh, MW Chapleau, SC Harwani… - Immunologic …, 2014 - Springer
A powerful interaction between the autonomic and the immune systems plays a prominent
role in the initiation and maintenance of hypertension and significantly contributes to …

[HTML][HTML] Complement in atherosclerosis: friend or foe?

WS Speidl, SP Kastl, K Huber, J Wojta - Journal of Thrombosis and …, 2011 - Elsevier
Atherosclerosis is a chronic inflammatory disease and the complement system plays a
central role in innate immunity. Increasing evidence exists that the complement system is …

Relationship of serum C3 to fasting insulin, risk factors and previous ischaemic events in middle-aged men

A Muscari, G Massarelli, L Bastagli… - European heart …, 2000 - academic.oup.com
Aims Serum C3 is a powerful indicator of the risk of myocardial infarction, which correlates
with body mass index, serum lipids and blood pressure. This study was performed to …

Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate: comparison study in an …

A Muscari, S Antonelli, G Bianchi, G Cavrini… - Diabetes …, 2007 - Am Diabetes Assoc
OBJECTIVE—This study was performed to ascertain the relative relevance of some
inflammatory markers in insulin resistance. RESEARCH DESIGN AND METHODS—Four …

Canonical and non-canonical roles of complement in atherosclerosis

P Maffia, C Mauro, A Case, C Kemper - Nature Reviews Cardiology, 2024 - nature.com
Cardiovascular diseases are the leading cause of death globally, and atherosclerosis is the
major contributor to the development and progression of cardiovascular diseases. Immune …

Insulin action and insulinemia are closely related to the fasting complement C3, but not acylation stimulating protein concentration.

C Weyer, PA Tataranni, RE Pratley - Diabetes Care, 2000 - Am Diabetes Assoc
OBJECTIVE: An elevated C3 concentration has been reported in people with obesity, type 2
diabetes, hypertension, and dyslipidemia, and has been proposed to play a role in the …

Association of high serum concentration of the third component of complement (C3) with pre-existing severe coronary artery disease and new vascular events in …

G Széplaki, Z Prohászka, J Duba, S Rugonfalvi-Kiss… - Atherosclerosis, 2004 - Elsevier
Atherosclerosis is an inflammatory disease. The complement system plays an important role
in the atherosclerotic process. However, lesser data is available on the possible role of C3 …

Complement C3 and its polymorphism: biological and clinical consequences

JR Delanghe, R Speeckaert… - Pathology-Journal of the …, 2014 - journals.lww.com
Complement 3 (C3) is a crucial component of the innate immune system, which in
association with other complement proteins, forms a major host mechanism for detection …