Mechanisms of dexmedetomidine in neuropathic pain

Y Zhao, J He, N Yu, C Jia, S Wang - Frontiers in neuroscience, 2020 - frontiersin.org
Dexmedetomidin is a new-generation, highly selective α2 adrenergic receptor agonist with a
large number of advantages, including its sedative and analgesic properties, its ability to …

Inflammatory mediators drive neuroinflammation in autism spectrum disorder and cerebral palsy

UTT Than, LT Nguyen, PH Nguyen, XH Nguyen… - Scientific Reports, 2023 - nature.com
Inflammation conditions are associated with autism spectrum disorder (ASD) and cerebral
palsy (CP), primarily observed in the peripheral immune system. However, the extent of …

Delivering paediatric precision medicine: Genomic and environmental considerations along the causal pathway of childhood neurodevelopmental disorders

S Woolfenden, MA Farrar, V Eapen… - … Medicine & Child …, 2022 - Wiley Online Library
Precision medicine refers to treatments that are targeted to an individual's unique
characteristics. Precision medicine for neurodevelopmental disorders (such as cerebral …

Prenatal exposure to ambient air pollution and cerebral palsy

Y Zhang, Y Hu, R Talarico, X Qiu, J Schwartz… - JAMA Network …, 2024 - jamanetwork.com
Importance Air pollution is associated with structural brain changes, disruption of
neurogenesis, and neurodevelopmental disorders. The association between prenatal …

Persistent inflammation in cerebral palsy: pathogenic mediator or comorbidity? a scoping review

MCB Paton, M Finch-Edmondson, RC Dale… - Journal of Clinical …, 2022 - mdpi.com
Research has established inflammation in the pathogenesis of brain injury and the risk of
developing cerebral palsy (CP). However, it is unclear if inflammation is solely pathogenic …

TNAP—a potential cytokine in the cerebral inflammation in spastic cerebral palsy

XK Wang, C Gao, HQ Zhong, XY Kong… - Frontiers in Molecular …, 2022 - frontiersin.org
Objective: Several studies have shown the significance of neuroinflammation in the
pathological progress of cerebral palsy (CP). However, the etiology of CP remains poorly …

Motor deficits are associated with increased glial cell activation in the hypothalamus and cerebellum of young rats subjected to cerebral palsy

BJR Costa-de-Santana, R Manhães-de-Castro… - Brain Research, 2023 - Elsevier
Cerebral palsy (CP) is a syndrome characterized by a wide range of sensory and motor
damage, associated with behavioral and cognitive deficits. The aim of the present study was …

Advances in cerebral palsy biomarkers

ZA Savasan, SK Kim, KJ Oh, SF Graham - Advances in clinical chemistry, 2021 - Elsevier
Cerebral palsy (CP), defined as a group of nonprogressive disorders of movement and
posture, is the most common cause of severe neurodisability in children. The prevalence of …

Creatine supplementation increases postnatal growth and strength and prevents overexpression of pro-inflammatory interleukin 6 in the hippocampus in an …

HJCB Gouveia, R Manhães-de-Castro… - Nutritional …, 2024 - Taylor & Francis
Objectives: The aim of this study was thus to evaluate the effect of Cr supplementation on
morphological changes and expression of pro-inflammatory cytokines in the hippocampus …

A preliminary model of football-related neural stress that integrates metabolomics with transcriptomics and virtual reality

NL Vike, S Bari, K Stetsiv, A Walter, S Newman… - Iscience, 2022 - cell.com
Research suggests contact sports affect neurological health. This study used permutation-
based mediation statistics to integrate measures of metabolomics, neuroinflammatory …