Platelets, non-nucleated blood components first described over 130 years ago, are
recognized as the primary cell regulating hemostasis and thrombosis. The vascular …

The immune system is an evolutionary hallmark of higher organisms that defends the host
against invading pathogens and exogenous infections. This defense includes the …

There is growing recognition of the critical role of platelets in inflammation and immune
responses. Recent studies have indicated that antiplatelet medications may reduce mortality …

Cardiovascular disease and cancer are the 2 leading causes of death worldwide. Emerging
evidence suggests common mechanisms between cancer and cardiovascular disease …

Platelets are essential effector cells in hemostasis. Aside from their role in coagulation,
platelets are now recognized as major inflammatory cells with key roles in the innate and …

Platelets contribute to processes beyond thrombus formation and may play a so far
underestimated role as an immune cell in various circumstances. This review outlines …

Platelets are chief effector cells in hemostasis. In addition, they are multifaceted
inflammatory cells with functions that span the continuum from innate immune responses to …

Platelets are among the most abundant cells in the mammalian circulation. Classical platelet
functions in hemostasis and wound healing have been intensively explored and are …

The inflammasomes control the bioactivity of pro-inflammatory cytokines of the interleukin
(IL)-1 family. The inflammasome assembled by NLRP3 has been predominantly studied in …

The paradigm of platelets as mere mediators of hemostasis has long since been replaced by
a dual role: hemostasis and inflammation. Now recognized as key players in innate and …