Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate
gene expression both spatially and temporally. Numerous biochemical, physiological, and …

Exosomes are cell-derived membranous structures primarily involved in the delivery of the
payload to the recipient cells, and they play central roles in carcinogenesis and metastasis …

To discover new potential pesticide candidates, recently, structural modification of natural
bioactive products has received much attention. In this work, a series of new piperine-type …

Piperine is a plant-derived promising piperamide candidate isolated from the black pepper
(Piper nigrum L.). In the last few years, this natural botanical product and its derivatives have …

Alkamides refer to a class of natural active small-molecule products composed of fatty acids
and amine groups. These compounds are widely distributed in plants, and their unique …

The global prevalence of diabetes and its related complications has increased drastically
and is currently a worldwide health challenge. There is still an urgent need for safe and …

Chemotherapy with doxorubicin (Dox) can lead to cardiotoxic effects, presenting a major
complication in cancer therapy. Diindolylmethane (DIM), derived from cruciferous …

Brain tumors, particularly astrocytomas, are a leading cause of cancer-related deaths.
MicroRNAs (miRNAs) are small, non-coding RNA molecules that control post-transcriptional …

Os produtos naturais têm motivado a humanidade a descobrir novos agentes terapêuticos
para várias doenças, especialmente as cancerígenas. Os carcinomas escamosos de …

Background Hepatocellular carcinoma (HCC) is the most common primary malignancy of
the liver, which the 5-year survival rate has not substantially improved in the past few …