Progesterone receptors (PR) are critical mediators of mammary gland development and
contribute to breast cancer progression. Progestin-induced rapid activation of cytoplasmic …

Cellular senescence is a stable state of proliferative arrest that provides a barrier against
malignant transformation and contributes to the antitumor activity of certain chemotherapies …

CK2 is a pleiotropic protein kinase, which regulates many survival pathways and plays a
global anti-apoptotic function. It is highly expressed in tumor cells, and is presently …

The molecular mechanisms that restore intestinal epithelial homeostasis during colitis are
incompletely understood. Here, we report that during intestinal inflammation, multiple …

Increased CK2 levels are prevalent in many cancers. Combined with the critical role CK2
plays in many cell-signaling pathways, this makes it a prime target for down regulation to …

Background The DNA-dependent protein kinase (DNA-PK) is a nuclear complex composed
of a large catalytic subunit (DNA-PKcs) and a heterodimeric DNA-targeting subunit Ku. DNA …

Protein Kinase CK2, a constitutively active serine/threonine kinase, fulfills its functions via
phosphorylating hundreds of proteins in nearly all cells. It regulates a variety of cellular …

Radioresistance is considered as a main factor restricting efficacy of radiotherapy. However,
the exact molecular mechanism of radioresistance has not been explained yet. In this study …

Substrate pleiotropicity, a very acidic phosphorylation consensus sequence, and an
apparent uncontrolled activity, are the main features of CK2, a Ser/Thr protein kinase that is …

Simple Summary Glioblastoma is the most common malignant brain cancer and is
associated with poor prognosis, with an average survival after diagnosis of less than 18 …