Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Mitochondrial dysfunction is increasingly implicated in the etiology of drug-induced toxicities.
Members of diverse drug classes undermine mitochondrial function, and among the most …

Drug resistance is a major hurdle for the effectiveness of tamoxifen (TAM) to provide clinical
benefit. Therefore, it is essential to identify a sensitizer that could be used to improve TAM …

There has been increasing evidence pointing to the mitochondrial respiratory chain (MRC)
as a novel and important target for the actions of 17β-estradiol (E2) and estrogen receptors …

Breast cancer is a heterogeneous disease affecting thousands of people every year.
Multiple factors are responsible in causing breast cancer while a number of treatment …

It is now well established that mitochondria accumulate Ca2+ ions during cytosolic Ca2+
([Ca2+] i) elevations in a variety of cell types including cardiomyocytes. Elevations in …

Here, we show that tamoxifen resistance is induced by cancer-associated fibroblasts (CAFs).
Coculture of estrogen receptor positive (ER+) MCF7 cells with fibroblasts induces tamoxifen …

Background Nonalcoholic fatty disease (NAFLD) is the most common liver disease, since it
is strongly associated with obesity and metabolic syndrome pandemics. NAFLD may affect …

Background Current recommendations that cancer patients receive a maximum cumulative
dose of 900 mg/m2 epirubicin are based on the risk of epirubicin-mediated cardiotoxicity …

Drug-induced liver injury (DILI) is an important cause of liver toxicity which can have varying
clinical presentations, the most severe of which being acute liver failure. Hepatocyte death …