Spinal muscular atrophy (SMA) is a neurodegenerative disorder caused by mutations in
SMN1 (encoding survival motor neuron protein (SMN)). Reduced expression of SMN leads …

The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …

Gene regulation requires the dynamic coordination of hundreds of regulatory factors at
precise genomic and RNA targets. Although many regulatory factors have specific affinity for …

The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades
of biochemistry and genetics combined with recent structural studies of the spliceosome …

The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …

RNA, DNA, and protein molecules are highly organized within three-dimensional (3D)
structures in the nucleus. Although RNA has been proposed to play a role in nuclear …

The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a
transcription initiation complex, and a transition to an elongation complex,,–. The large …

Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …

Summary The N 6-methyladenosine (m 6 A) RNA modification is used widely to alter the fate
of mRNAs. Here we demonstrate that the C. elegans writer METT-10 (the ortholog of mouse …

The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …