[图书][B] Histopathology of preclinical toxicity studies: interpretation and relevance in drug safety evaluation

P Greaves - 2011 - books.google.com
Chapter 1: Introduction--Chapter 2: Integumentary System----Skin and subcutaneous tissue--
Chapter 3: Mammary Gland--Chapter 4: Haemopoietic and Lymphatic Systems …

The flaws and future of islet volume measurements

HH Huang, S Harrington… - Cell …, 2018 - journals.sagepub.com
When working with isolated islet preparations, measuring the volume of tissue is not a trivial
matter. Islets come in a large range of sizes and are often contaminated with exocrine tissue …

[HTML][HTML] FEM-based oxygen consumption and cell viability models for avascular pancreatic islets

P Buchwald - Theoretical Biology and Medical Modelling, 2009 - Springer
Background The function and viability of cultured, transplanted, or encapsulated pancreatic
islets is often limited by hypoxia because these islets have lost their vasculature during the …

Small rat islets are superior to large islets in in vitro function and in transplantation outcomes

RR MacGregor, SJ Williams, PY Tong… - American Journal …, 2006 - journals.physiology.org
Barriers to the use of islet transplantation as a practical treatment for diabetes include the
limited number of available donor pancreata. This project was designed to determine …

The ductal origin of structural and functional heterogeneity between pancreatic islets

C Merkwitz, OW Blaschuk, A Schulz… - … in histochemistry and …, 2013 - Elsevier
Islets form in the pancreas after the first endocrine cells have arisen as either single cells or
small cell clusters in the epithelial cords. These cords constitute the developing pancreas in …

Quantitative assessment of islet cell products: estimating the accuracy of the existing protocol and accounting for islet size distribution

P Buchwald, X Wang, A Khan, A Bernal… - Cell …, 2009 - journals.sagepub.com
The ability to consistently and reliably assess the total number and the size distribution of
isolated pancreatic islet cells from a small sample is of crucial relevance for the adequate …

Small human islets comprised of more β-cells with higher insulin content than large islets

B Farhat, A Almelkar, K Ramachandran, SJ Williams… - Islets, 2013 - Taylor & Francis
For the past 30 y, data have suggested that unique islet populations exist, based on
morphology and glucose sensitivity. Yet little has been done to determine the mechanism of …

Low insulin content of large islet population is present in situ and in isolated islets

HH Huang, L Novikova, SJ Williams, IV Smirnova… - Islets, 2011 - Taylor & Francis
The existence of morphologically distinct populations of islets in the pancreas was described
over 60 years ago. Unfortunately, little attention has been paid to possible functional …

Fully automated islet cell counter (ICC) for the assessment of islet mass, purity, and size distribution by digital image analysis

P Buchwald, A Bernal, F Echeverri… - Cell …, 2016 - journals.sagepub.com
For isolated pancreatic islet cell preparations, it is important to be able to reliably assess
their mass and quality, and for clinical applications, it is part of the regulatory requirement …

Ultrastructural analysis, zinc transporters, glucose transporters and hormones expression in New world primate (Callithrix jacchus) and human pancreatic islets

D Mohanasundaram, C Drogemuller, J Brealey… - General and …, 2011 - Elsevier
The New world primates (NWP) Callithrix jacchus separated from man approximately
50million years ago and is a potential alternative small non-human primate model for …