COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …

The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …

Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …

Endothelial tight junctions (TJs) regulate the transport of water, ions, and molecules through
the paracellular pathway, serving as an important barrier in blood vessels and maintaining …

Since the first attempts in the 1970s to isolate cerebral microvessel endothelial cells (CECs)
in order to model the blood–brain barrier (BBB) in vitro, the need for a human BBB model …

Harmful materials in the blood are prevented from entering the healthy brain by a highly
selective blood–brain barrier (BBB), and impairment of barrier function has been associated …

The Blood–brain barrier (BBB), present at the level of the endothelium of cerebral blood
vessels, selectively restricts the blood-to-brain paracellular diffusion of compounds; it is …

Cerebrovascular disease (CVD) and Alzheimer's disease (AD) have more in common than
their association with ageing. They share risk factors and overlap neuropathologically. Most …

There is growing evidence suggesting that vascular pathologies and dysfunction play a
critical role in cognitive impairment, clinical Alzheimer's disease, and dementia. Vascular …

The blood–brain barrier (BBB), which is formed by adherens and tight junctions (TJs) of
endothelial cells, maintains homeostasis of the brain. Disrupted intracellular Ca2+ …