An integrated molecular landscape implicates the regulation of dendritic spine formation through insulin-related signalling in obsessive–compulsive disorder
I van de Vondervoort, G Poelmans, A Aschrafi… - Journal of Psychiatry and …, 2016 - jpn.ca
Background: Obsessive–compulsive disorder (OCD) is a neuropsychiatric disorder with
onset in childhood and is characterized by obsessions (recurrent, intrusive, persistent …
onset in childhood and is characterized by obsessions (recurrent, intrusive, persistent …
Understanding the covariation of tics, attention‐deficit/hyperactivity, and obsessive‐compulsive symptoms: A population‐based adult twin study
R Pinto, B Monzani, JF Leckman… - American Journal of …, 2016 - Wiley Online Library
Chronic tic disorders (TD), attention‐deficit/hyperactivity‐disorder (ADHD), and obsessive‐
compulsive disorder (OCD) frequently co‐occur in clinical and epidemiological samples …
compulsive disorder (OCD) frequently co‐occur in clinical and epidemiological samples …
A population-based family clustering study of tic-related obsessive-compulsive disorder
In the latest edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5),
obsessive-compulsive disorder (OCD) included a new “tic-related” specifier. However …
obsessive-compulsive disorder (OCD) included a new “tic-related” specifier. However …
Polygenic risk scores derived from a Tourette syndrome genome-wide association study predict presence of tics in the avon longitudinal study of parents and children …
Background Tourette syndrome (TS) has a well-established genetic background, but its
genetic architecture remains largely unknown. The authors investigated the role of polygenic …
genetic architecture remains largely unknown. The authors investigated the role of polygenic …
Single nucleotide polymorphism heritability of behavior problems in childhood: genome-wide complex trait analysis
Objective Genetic factors contribute to individual differences in behavior problems. In
children, genome-wide association studies (GWAS) have yielded the first suggestive results …
children, genome-wide association studies (GWAS) have yielded the first suggestive results …
Leveraging allelic imbalance to refine fine-mapping for eQTL studies
Many disease risk loci identified in genome-wide association studies are present in non-
coding regions of the genome. Previous studies have found enrichment of expression …
coding regions of the genome. Previous studies have found enrichment of expression …
Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating
EV Ho, A Welch, SL Thompson, JA Knowles… - Plos one, 2023 - journals.plos.org
Protein Tyrosine Phosphatase receptor type D (PTPRD) is a member of the protein tyrosine
phosphatase family that mediates cell adhesion and synaptic specification. Genetic studies …
phosphatase family that mediates cell adhesion and synaptic specification. Genetic studies …
Identification of two heritable cross-disorder endophenotypes for Tourette syndrome
SM Darrow, ME Hirschtritt, LK Davis… - American Journal of …, 2017 - Am Psychiatric Assoc
Objective: Phenotypic heterogeneity in Tourette syndrome is partly due to complex genetic
relationships among Tourette syndrome, obsessive-compulsive disorder (OCD), and …
relationships among Tourette syndrome, obsessive-compulsive disorder (OCD), and …
Histidine decarboxylase knockout mice as a model of the pathophysiology of Tourette syndrome and related conditions
C Pittenger - Histamine and Histamine Receptors in Health and …, 2017 - Springer
While the normal functions of histamine (HA) in the central nervous system have gradually
come into focus over the past 30 years, the relationship of abnormalities in neurotransmitter …
come into focus over the past 30 years, the relationship of abnormalities in neurotransmitter …
Tourette disorder and other tic disorders
Tourette disorder is a developmental neuropsychiatric condition characterized by vocal and
motor tics that can range in severity from mild to disabling. It represents one end of a …
motor tics that can range in severity from mild to disabling. It represents one end of a …