Cancer genome landscapes
Over the past decade, comprehensive sequencing efforts have revealed the genomic
landscapes of common forms of human cancer. For most cancer types, this landscape …
landscapes of common forms of human cancer. For most cancer types, this landscape …
PI3K/AKT signaling pathway and cancer: an updated review
Despite development of novel agents targeting oncogenic pathways, matching targeted
therapies to the genetic status of individual tumors is proving to be a daunting task for …
therapies to the genetic status of individual tumors is proving to be a daunting task for …
[HTML][HTML] Biological role and therapeutic potential of IDH mutations in cancer
Hotspot mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2
(IDH2) occur in a variety of myeloid malignancies and solid tumors. Mutant IDH proteins …
(IDH2) occur in a variety of myeloid malignancies and solid tumors. Mutant IDH proteins …
Mechanisms underlying mutational signatures in human cancers
The collective somatic mutations observed in a cancer are the outcome of multiple
mutagenic processes that have been operative over the lifetime of a patient. Each process …
mutagenic processes that have been operative over the lifetime of a patient. Each process …
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases
Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …
[HTML][HTML] Microbiome in cancer: Role in carcinogenesis and impact in therapeutic strategies
Cancer is the world's second-leading cause of death, and the involvement of microbes in a
range of diseases, including cancer, is well established. The gut microbiota is known to play …
range of diseases, including cancer, is well established. The gut microbiota is known to play …
[HTML][HTML] Comprehensive molecular characterization of human colon and rectal cancer
Cancer Genome Atlas Network - Nature, 2012 - ncbi.nlm.nih.gov
To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale
analysis of 276 samples, analysing exome sequence, DNA copy number, promoter …
analysis of 276 samples, analysing exome sequence, DNA copy number, promoter …
[HTML][HTML] Wnt/β-catenin signaling and disease
The WNT signal transduction cascade controls myriad biological phenomena throughout
development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a …
development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a …
[HTML][HTML] Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS international consortium
Abstract Fibrous Dysplasia/McCune Albright syndrome (FD/MAS) represents a wide
spectrum of diseases due to somatic gain-of-function mutations of the GNAS gene. The …
spectrum of diseases due to somatic gain-of-function mutations of the GNAS gene. The …
[HTML][HTML] A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis
M Fujii, M Shimokawa, S Date, A Takano, M Matano… - Cell stem cell, 2016 - cell.com
Colorectal tumor is a heterogeneous disease, with varying clinical presentation and
prognosis in patients. To establish a platform encompassing this diversity, we generated 55 …
prognosis in patients. To establish a platform encompassing this diversity, we generated 55 …