Over the past decade, comprehensive sequencing efforts have revealed the genomic
landscapes of common forms of human cancer. For most cancer types, this landscape …

Despite development of novel agents targeting oncogenic pathways, matching targeted
therapies to the genetic status of individual tumors is proving to be a daunting task for …

Hotspot mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2
(IDH2) occur in a variety of myeloid malignancies and solid tumors. Mutant IDH proteins …

The collective somatic mutations observed in a cancer are the outcome of multiple
mutagenic processes that have been operative over the lifetime of a patient. Each process …

Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …

Cancer is the world's second-leading cause of death, and the involvement of microbes in a
range of diseases, including cancer, is well established. The gut microbiota is known to play …

To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale
analysis of 276 samples, analysing exome sequence, DNA copy number, promoter …

The WNT signal transduction cascade controls myriad biological phenomena throughout
development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a …

Abstract Fibrous Dysplasia/McCune Albright syndrome (FD/MAS) represents a wide
spectrum of diseases due to somatic gain-of-function mutations of the GNAS gene. The …

Colorectal tumor is a heterogeneous disease, with varying clinical presentation and
prognosis in patients. To establish a platform encompassing this diversity, we generated 55 …