Increased oxidative stress has been suggested to initiate and promote tumorigenesis by
inducing DNA damage and to suppress tumor development by triggering apoptosis and …

Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …

Predicting the best treatment strategy from genomic information is a core goal of precision
medicine. Here we focus on predicting drug response based on a cohort of genomic …

Colorectal cancer (CRC) presents a considerable disease burden worldwide. The human
colon is also an anatomical location with the largest number of microbes. It is natural …

Oncogenic KRAS (KRAS*) contributes to many cancer hallmarks. In colorectal cancer,
KRAS* suppresses antitumor immunity to promote tumor invasion and metastasis. Here, we …

The genome of a cancer cell carries somatic mutations that are the cumulative
consequences of the DNA damage and repair processes operative during the cellular …

Approximately 2% of colorectal cancer is linked to pre-existing inflammation known as colitis-
associated cancer, but most develops in patients without underlying inflammatory bowel …

Aneuploidy has been recognized as a hallmark of cancer for more than 100 years, yet no
general theory to explain the recurring patterns of aneuploidy in cancer has emerged. Here …

The past decade has highlighted the central role of epigenetic processes in cancer
causation, progression and treatment. Next-generation sequencing is providing a window …

The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …