Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …

The cancer stem cell (CSC) model has been established as a cellular mechanism that
contributes to phenotypic and functional heterogeneity in diverse cancer types. Recent …

Development of cancer has been linked to chronic inflammation, particularly via interleukin-
23 (IL-23) and IL-17 signaling pathways. However, the cellular source of IL-17 and …

Carcinogenesis is a mechanistically complex and variable process with a plethora of
underlying genetic causes. Cancer development comprises a multitude of steps that occur …

Breast carcinoma is the leading cause of cancer-related mortality in women worldwide, with
an estimated 1.38 million new cases and 458,000 deaths in 2008 alone. This malignancy …

Identifying and understanding changes in cancer genomes is essential for the development
of targeted therapeutics. Here we analyse systematically more than 70 pairs of primary …

Background Myelodysplastic syndromes are clinically heterogeneous disorders
characterized by clonal hematopoiesis, impaired differentiation, peripheral-blood …

Today, clinical evaluation of tumor heterogeneity is an emergent issue to improve clinical
oncology. In particular, intra-tumor heterogeneity (ITH) is closely related to cancer …

Sequencing has identified millions of somatic mutations in human cancers, but
distinguishing cancer driver genes remains a major challenge. Numerous methods have …

Metastasis is a complex, multistep process responsible for> 90% of cancer-related deaths. In
addition to genetic and external environmental factors, the physical interactions of cancer …