Tumor heterogeneity: causes and consequences
A Marusyk, K Polyak - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2010 - Elsevier
With rare exceptions, spontaneous tumors originate from a single cell. Yet, at the time of
clinical diagnosis, the majority of human tumors display startling heterogeneity in many …
clinical diagnosis, the majority of human tumors display startling heterogeneity in many …
Epigenetics and colorectal cancer
VV Lao, WM Grady - Nature reviews Gastroenterology & hepatology, 2011 - nature.com
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are
frequently associated with tumorigenesis. Deep sequencing studies show that 4.2% of …
frequently associated with tumorigenesis. Deep sequencing studies show that 4.2% of …
Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
Ovarian clear cell carcinoma (OCCC) is an aggressive human cancer that is generally
resistant to therapy. To explore the genetic origin of OCCC, we determined the exomic …
resistant to therapy. To explore the genetic origin of OCCC, we determined the exomic …
The genetic landscape of mutations in Burkitt lymphoma
Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other
genetic mutations to the disease is largely unknown. Here, we describe the first completely …
genetic mutations to the disease is largely unknown. Here, we describe the first completely …
The spectrum of SWI/SNF mutations, ubiquitous in human cancers
AH Shain, JR Pollack - PloS one, 2013 - journals.plos.org
SWI/SNF is a multi-subunit chromatin remodeling complex that uses the energy of ATP
hydrolysis to reposition nucleosomes, thereby modulating gene expression. Accumulating …
hydrolysis to reposition nucleosomes, thereby modulating gene expression. Accumulating …
The chromosomal instability pathway in colon cancer
MS Pino, DC Chung - Gastroenterology, 2010 - Elsevier
The acquisition of genomic instability is a crucial feature in tumor development and there are
at least 3 distinct pathways in colorectal cancer pathogenesis: the chromosomal instability …
at least 3 distinct pathways in colorectal cancer pathogenesis: the chromosomal instability …
A decade's perspective on DNA sequencing technology
ER Mardis - Nature, 2011 - nature.com
The decade since the Human Genome Project ended has witnessed a remarkable
sequencing technology explosion that has permitted a multitude of questions about the …
sequencing technology explosion that has permitted a multitude of questions about the …
An integrated genomic analysis of human glioblastoma multiforme
DW Parsons, S Jones, X Zhang, JCH Lin, RJ Leary… - science, 2008 - science.org
Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To
identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes …
identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes …
Advances in understanding cancer genomes through second-generation sequencing
Cancers are caused by the accumulation of genomic alterations. Therefore, analyses of
cancer genome sequences and structures provide insights for understanding cancer …
cancer genome sequences and structures provide insights for understanding cancer …