With rare exceptions, spontaneous tumors originate from a single cell. Yet, at the time of
clinical diagnosis, the majority of human tumors display startling heterogeneity in many …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …

Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are
frequently associated with tumorigenesis. Deep sequencing studies show that 4.2% of …

Ovarian clear cell carcinoma (OCCC) is an aggressive human cancer that is generally
resistant to therapy. To explore the genetic origin of OCCC, we determined the exomic …

Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other
genetic mutations to the disease is largely unknown. Here, we describe the first completely …

SWI/SNF is a multi-subunit chromatin remodeling complex that uses the energy of ATP
hydrolysis to reposition nucleosomes, thereby modulating gene expression. Accumulating …

The acquisition of genomic instability is a crucial feature in tumor development and there are
at least 3 distinct pathways in colorectal cancer pathogenesis: the chromosomal instability …

The decade since the Human Genome Project ended has witnessed a remarkable
sequencing technology explosion that has permitted a multitude of questions about the …

Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To
identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes …

Cancers are caused by the accumulation of genomic alterations. Therefore, analyses of
cancer genome sequences and structures provide insights for understanding cancer …