During the past 6 years, considerable advancement has been achieved in experimental
embryology of pigs. This process was mainly generated by the rapidly increasing need for …

The enzyme α1, 3-galactosyltransferase (α1, 3GT or GGTA1) synthesizes α1, 3-galactose
(α1, 3Gal) epitopes (Galα1, 3Galβ1, 4GlcNAc-R), which are the major xenoantigens causing …

Commercially available human acellular dermal matrix (HADM), AlloDerm®, was implanted
as an interpositional graft in the abdominal wall of adult vervet monkeys. Host response to …

OBJECTIVES: Transplantation is limited by a lack of human organ donors. Organs derived
from animals, most likely the pig, represent a potential solution to this problem. For the heart …

We describe the generation and analysis of an integrated sequence map of a 2.4-Mb region
of pig chromosome 7, comprising the classical class I region, the extended and classical …

Over the last quarter of the 20th century, there has been a boom in biomedical research
discoveries that, for the most part, has not been successfully exploited for improving medical …

The curative promise of stem cells and their descendants for tissue regeneration and repair
is currently the subject of an intense research effort worldwide. If it proves feasible to …

Background. The major antigen recognized on pig tissue by primate antibodies is a terminal
galα1-3gal carbohydrate structure (gal antigen) present on glycolipids and glycoproteins …

The use of α1, 3-galactosyltransferase gene-knockout (GalT-KO) swine donors in discordant
xenotransplantation has extended the survival of cardiac xenografts in baboons following …

Background: Experience with non‐antigenic galactose α1, 3 galactose (αGal) polymers and
development of αGal deficient pigs has reduced or eliminated the significance of this antigen …