Despite considerable efforts, malaria is still one of the most devastating infectious diseases
in the tropics. The rapid spread of antimalarial drug resistance currently compounds this …

The development of resistance to drugs poses one of the greatest threats to malaria control.
In Africa, the efficacy of readily affordable antimalarial drugs is declining rapidly, while highly …

Multidrug resistance has rendered monotherapy for malaria useless in most parts of the
world, and has also compromised the usefulness of many of the available combination …

Objectives To determine:(1) the pharmacokinetics and safety of an investigational
aminoquinoline active against multidrug–resistant malaria parasites (AQ-13), including its …

Plasmodium falciparum malaria in pregnancy poses substantial risk to a pregnant woman
and her neonate through anaemia and low birth weight (LBW), respectively, and is …

Summary Background Increasing Plasmodium falciparum resistance to chloroquine in sub-
Saharan Africa necessitates use of alternative antimalarial agents. Affordable alternative …

Chloroquine remains the first-line therapy for uncomplicated malaria in Indonesia. Among a
series of trials of chloroquine for malaria on this archipelago conducted since 1990, we now …

Chloroquine (CHQ) is a cheap, relatively well tolerated drug initially developed for the
treatment of malaria in the 1930s. CHQ has, however, since accrued a plethora of uses in …

Chloroquine (CQ) resistance was first documented in Uganda in 1988. Subsequent
surveillance of antimalarial drug resistance, conducted by the Ugandan Ministry of Health …

Importance of the field: Malaria infection during pregnancy is a major public health problem
worldwide, with 50 million pregnancies exposed to the infection every year. Approximately …