In the central nervous system (CNS), astrocytes form networks interconnected by gap
junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an …

A high-intensity potentially tissue-injuring stimulus generates a homotopic response to
escape the stimulus and is associated with an affective phenotype considered to represent …

The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …

Immune and glial cells play a pivotal role in chronic pain. Therefore, it is possible that the
pharmacological modulation of neurotransmission from an exclusively neuronal perspective …

Chronic abdominal pain is the most common gastrointestinal issue and contributes to the
pathophysiology of functional bowel disorders and inflammatory bowel disease. Current …

The cis benzopyran compound tonabersat (SB-220453) has previously been reported to
inhibit connexin26 expression in the brain by attenuating the p38-mitogen-activated protein …

Abstract Sigma-1 receptor (σ1R) knockout (KO) CD1 mice, generated by homologous
recombination, and separate pharmacological studies in wild type (WT) mice were done to …

Though a great many of studies on the development of antidepressants for the therapy of
major depression disorder (MDD) and the development of antidepressants have been …

Spinal cord injury (SCI) is globally considered as one of the most debilitating disorders,
which interferes with daily activities and life of the affected patients. Despite many …

Neuronal survival, electrical signaling and synaptic activity require a well-balanced micro-
environment in the central nervous system. This is achieved by the blood–brain barrier …