Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …

The activation of mostly quiescent haematopoietic stem cells (HSCs) is a prerequisite for life-
long production of blood cells. This process requires major molecular adaptations to allow …

Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of
haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly …

The dogma that adaptive immunity is the only arm of the immune response with memory
capacity has been recently challenged by several studies demonstrating evidence for …

The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …

A greater understanding of hematopoietic stem cell (HSC) regulation is required for
dissecting protective versus detrimental immunity to pathogens that cause chronic infections …

Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …

Bone marrow transplantation therapy relies on the life-long regenerative capacity of
haematopoietic stem cells (HSCs),. HSCs present a complex variety of regenerative …

Bioconductor is an open-source, open-development software project for the analysis and
comprehension of high-throughput data in genomics and molecular biology. The project …