Polymeric nanoparticle vaccines to combat emerging and pandemic threats
D Wibowo, SHT Jorritsma, ZJ Gonzaga, B Evert… - Biomaterials, 2021 - Elsevier
Subunit vaccines are more advantageous than live attenuated vaccines in terms of safety
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …
Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine …
Uncleaved prefusion-optimized (UFO) design can stabilize diverse HIV-1 envelope
glycoproteins (Envs). Single-component, self-assembling protein nanoparticles (1c-SApNP) …
glycoproteins (Envs). Single-component, self-assembling protein nanoparticles (1c-SApNP) …
Interests of the non-human primate models for HIV cure research
G Terrade, N Huot, C Petitdemange, M Lazzerini… - Vaccines, 2021 - mdpi.com
Non-human primate (NHP) models are important for vaccine development and also
contribute to HIV cure research. Although none of the animal models are perfect, NHPs …
contribute to HIV cure research. Although none of the animal models are perfect, NHPs …
Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens
A Antanasijevic, G Ueda, PJM Brouwer, J Copps… - PLoS …, 2020 - journals.plos.org
Two-component, self-assembling nanoparticles represent a versatile platform for multivalent
presentation of viral antigens. Computational design of protein nanoparticles with differing …
presentation of viral antigens. Computational design of protein nanoparticles with differing …
CD4+ T Cell-Mimicking Nanoparticles Broadly Neutralize HIV-1 and Suppress Viral Replication through Autophagy
Therapeutic strategies that provide effective and broad‐spectrum neutralization against HIV-
1 infection are highly desirable. Here, we investigate the potential of nanoengineered CD4+ …
1 infection are highly desirable. Here, we investigate the potential of nanoengineered CD4+ …
Periodic mesoporous organosilica as a nanoadjuvant for subunit vaccines elicits potent antigen-specific germinal center responses by activating naive B cells
F Li, X Feng, J Huang, M Zhang, W Liu, X Wang… - ACS …, 2023 - ACS Publications
Infection diseases such as AIDS and COVID-19 remain challenging in regard to protective
vaccine design, while adjuvants are critical for subunit vaccines to induce strong, broad, and …
vaccine design, while adjuvants are critical for subunit vaccines to induce strong, broad, and …
Surface-functionalized silica-coated calcium phosphate nanoparticles efficiently deliver DNA-based HIV-1 trimeric envelope vaccines against HIV-1
S Li, B Wang, S Jiang, Y Pan, Y Shi… - … Applied Materials & …, 2021 - ACS Publications
Human immunodeficiency virus type 1 (HIV-1) infection remains one of the worst crises in
global health. The prevention of HIV-1 infection is a crucial task that needs to be addressed …
global health. The prevention of HIV-1 infection is a crucial task that needs to be addressed …
Multivalent display of engineered HIV-1 envelope trimers on silica nanoparticles for targeting and in vitro activation of germline VRC01 B cells
D Peterhoff, S Thalhauser, P Neckermann… - European Journal of …, 2022 - Elsevier
Selective targeting of germline B cells with specifically designed germline-targeting HIV-1
envelope immunogens (GT-Env) is considered a feasible vaccination strategy to elicit …
envelope immunogens (GT-Env) is considered a feasible vaccination strategy to elicit …
Conjugation of native-like hiv-1 envelope trimers onto liposomes using edc/sulfo-nhs chemistry: Requirements and limitations
E Suleiman, J Mayer, E Lehner, B Kohlhauser… - Pharmaceutics, 2020 - mdpi.com
The display of native-like human immunodeficiency virus type 1 envelope (HIV-1 Env)
trimers on liposomes has gained wide attention over the last few years. Currently, available …
trimers on liposomes has gained wide attention over the last few years. Currently, available …
Augmenting the immune response against a stabilized HIV-1 clade C envelope trimer by silica nanoparticle delivery
D Peterhoff, S Thalhauser, JM Sobczak, MO Mohsen… - Vaccines, 2021 - mdpi.com
The delivery of HIV-1 envelope (Env) trimer-based immunogens on the surface of
nanoparticles holds promise to promote immunogenicity with the aim of inducing a potent …
nanoparticles holds promise to promote immunogenicity with the aim of inducing a potent …