A shift of paradigm: From avoiding nanoparticular complement activation in the field of nanomedicines to its exploitation in the context of vaccine development

C Barbey, H Wolf, R Wagner, D Pauly… - European Journal of …, 2023 - Elsevier
The complement system plays a central role in our innate immunity to fight pathogenic
microorganisms, foreign and altered cells, or any modified molecule. Consequences of …

[HTML][HTML] Augmenting the immune response against a stabilized HIV-1 clade C envelope trimer by silica nanoparticle delivery

D Peterhoff, S Thalhauser, JM Sobczak, MO Mohsen… - Vaccines, 2021 - mdpi.com
The delivery of HIV-1 envelope (Env) trimer-based immunogens on the surface of
nanoparticles holds promise to promote immunogenicity with the aim of inducing a potent …

Advanced material against human (including Covid‐19) and plant viruses: nanoparticles as a feasible strategy

GR Tortella, O Rubilar, MC Diez, J Padrão… - Global …, 2021 - Wiley Online Library
The SARS‐CoV‐2 virus outbreak revealed that these nano‐pathogens have the ability to
rapidly change lives. Undoubtedly, SARS‐CoV‐2 as well as other viruses can cause …

[HTML][HTML] Prolonged delivery of HIV-1 vaccine nanoparticles from hydrogels

R Mietzner, C Barbey, H Lehr, CE Ziegler… - International Journal of …, 2024 - Elsevier
Immunization is a straightforward concept but remains for some pathogens like HIV-1 a
challenge. Thus, new approaches towards increasing the efficacy of vaccines are required …

Production and Immunogenicity of FeLV Gag-Based VLPs Exposing a Stabilized FeLV Envelope Glycoprotein

R Ortiz, A Barajas, A Pons-Grífols, B Trinité… - Viruses, 2024 - mdpi.com
The envelope glycoprotein (Env) of retroviruses, such as the Feline leukemia virus (FeLV), is
the main target of neutralizing humoral response, and therefore, a promising vaccine …

[HTML][HTML] Nucleic Acid Vaccines Encoding Proteins and Virus-like Particles for HIV Prevention

F Tarrés-Freixas, B Clotet, J Carrillo, J Blanco - Vaccines, 2024 - mdpi.com
The development of HIV prophylactic vaccines is facing an impasse, since all phase IIb/III
clinical trials were halted in 2023 without demonstrating efficacy. Thus, the field is in need of …

Broad and potent bispecific neutralizing antibody gene delivery using adeno-associated viral vectors for passive immunization against HIV-1

S Li, Y Qiao, S Jiang, B Wang, W Kong… - Journal of Controlled …, 2021 - Elsevier
Broadly neutralizing antibodies (bNAbs) possess favorable safety, and passive
immunization using these can prevent or control human immunodeficiency virus type 1 (HIV …

[HTML][HTML] A Polylactide-Based Micellar Adjuvant Improves the Intensity and Quality of Immune Response

M Lamrayah, C Phelip, C Coiffier, C Lacroix, T Willemin… - Pharmaceutics, 2022 - mdpi.com
Micelles from amphiphilic polylactide-block-poly (N-acryloxysuccinimide-co-N-
vinylpyrrolidone)(PLA-bP (NAS-co-NVP)) block copolymers of 105 nm in size were …

Nanoparticle-based vaccines and future vaccine technologies

SS Vasudevan, TY Kandrikar, AA Sayyed… - … for Infectious and …, 2024 - Elsevier
Vaccination has been extremely effective in treating infectious illnesses for almost 200
years. Understanding immunology and advances in molecular biology have enabled the …

Nanotechnology: New frontiers in anti-HIV therapy

J Jampílek, K Kráľová - Nanotechnological Applications in Virology, 2022 - Elsevier
Viruses can be considered as one of the most common causes of human disease. The
human immunodeficiency virus (HIV) causing acquired immunodeficiency syndrome (AIDS) …