Recent evidence suggests that autophagy is a governed catabolic framework enabling the
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …

Addressing the need for effective cancer chemotherapy with low adverse effects has been
partially possible through innovative therapeutic approaches combining chemotherapeutics …

Autophagy is an evolutionarily conserved cellular system crucial for cellular homeostasis
that protects cells from a broad range of internal and extracellular stresses. Autophagy …

Autophagy is a fundamental homeostatic process in which certain cellular components are
ingested by double-membrane autophagosomes and then degraded to create energy or to …

Currently, therapies for treating oral cancer have various side effects; therefore, research on
treatment methods employing natural substances is being conducted. This study aimed to …

Autophagy is a critical cellular adaptive response in tumor formation. Nutritional deficiency
and hypoxia exacerbate autophagic flux in established malignancies, promoting tumor cell …

Lysosomes are organelles containing acidic hydrolases that are responsible for lysosomal
degradation and the maintenance of cellular homeostasis. They play an important role in …

Ovarian cancer, a highly lethal malignancy among reproductive organ cancers, poses a
significant challenge with its high mortality rate, particularly in advanced-stage cases …

Abstract Background Maackiain (Mac), a flavonoid analog isolated from Sophora flavescens,
exhibits neuroprotective, anti-allergic, anti-inflammatory, and pro-apoptotic effects. It is not …

Beclin-1 is the firstly-identified mammalian protein of the autophagy machinery, which
functions as a molecular scaffold for the assembly of PI3KC3 (class III phosphatidylinositol 3 …