Tumor microenvironment participates in metastasis of pancreatic cancer
B Ren, M Cui, G Yang, H Wang, M Feng, L You… - Molecular cancer, 2018 - Springer
Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early
diagnosis and metastasis. The tumor microenvironment induced by interactions between …
diagnosis and metastasis. The tumor microenvironment induced by interactions between …
CAF subpopulations: a new reservoir of stromal targets in pancreatic cancer
BA Pereira, C Vennin, M Papanicolaou, CR Chambers… - Trends in cancer, 2019 - cell.com
Cancer-associated fibroblasts (CAFs) are one of the most significant components in the
tumour microenvironment (TME), where they can perform several protumourigenic functions …
tumour microenvironment (TME), where they can perform several protumourigenic functions …
Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology
D Osuna de la Peña, SMD Trabulo, E Collin… - Nature …, 2021 - nature.com
Patient-derived in vivo models of human cancer have become a reality, yet their turnaround
time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully …
time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully …
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
Sonic hedgehog (Shh), a soluble ligand overexpressed by neoplastic cells in pancreatic
ductal adenocarcinoma (PDAC), drives formation of a fibroblast-rich desmoplastic stroma …
ductal adenocarcinoma (PDAC), drives formation of a fibroblast-rich desmoplastic stroma …
Cancer stem cell quiescence and plasticity as major challenges in cancer therapy
W Chen, J Dong, J Haiech, MC Kilhoffer… - Stem cells …, 2016 - Wiley Online Library
Cells with stem‐like properties, tumorigenic potential, and treatment‐resistant phenotypes
have been identified in many human malignancies. Based on the properties they share with …
have been identified in many human malignancies. Based on the properties they share with …
Tumour microenvironment of pancreatic cancer: immune landscape is dictated by molecular and histopathological features
E Karamitopoulou - British journal of cancer, 2019 - nature.com
Pancreatic cancer is a lethal disease, with fewer than 7% of patients surviving beyond 5
years following diagnosis. Immune responses are known to influence tumour progression …
years following diagnosis. Immune responses are known to influence tumour progression …
The pancreas cancer microenvironment
C Feig, A Gopinathan, A Neesse, DS Chan, N Cook… - Clinical cancer …, 2012 - AACR
Pancreatic ductal adenocarcinoma (PDA) is a common and lethal malignancy resulting in
more than 250,000 deaths per year worldwide. Despite extensive efforts, cytotoxic and …
more than 250,000 deaths per year worldwide. Despite extensive efforts, cytotoxic and …
Current advances and outlooks in immunotherapy for pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is an incurable cancer resistant to traditional
treatments, although a limited number of early-stage patients can undergo radical resection …
treatments, although a limited number of early-stage patients can undergo radical resection …
Cancer stem cells: the challenges ahead
JP Medema - Nature cell biology, 2013 - nature.com
Cancer stem cells (CSCs) have been proposed as the driving force of tumorigenesis and the
seeds of metastases. However, their existence and role remain a topic of intense debate …
seeds of metastases. However, their existence and role remain a topic of intense debate …
Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma
A Ene–Obong, AJ Clear, J Watt, J Wang, R Fatah… - Gastroenterology, 2013 - Elsevier
Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is characterized by a
prominent desmoplastic microenvironment that contains many different immune cells …
prominent desmoplastic microenvironment that contains many different immune cells …