In the last 5 years, most of the molecules that control mitochondrial Ca2+ homeostasis have
been finally identified. Mitochondrial Ca2+ uptake is mediated by the Mitochondrial Calcium …

Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

Rationale: Remote ischemic preconditioning (rIPC) with short episodes of
ischemia/reperfusion (I/R) of an organ remote from the heart is a powerful approach to …

Haemoglobins and myoglobins constitute related protein families that function in oxygen
transport and storage in humans and other vertebrates,. Here we report the identification of a …

Myoglobin is a cytoplasmic hemoprotein, expressed solely in cardiac myocytes and
oxidative skeletal muscle fibers, that reversibly binds O2 by its heme residue, a porphyrin …

The heart and those striated muscles that contract for long periods, having available almost
limitless oxygen, operate in sustained steady states of low sarcoplasmic oxygen pressure …

In this review we consider the effects of endogenous and pharmacological levels of nitrite
under conditions of hypoxia. In humans, the nitrite anion has long been considered as …

The nitrite anion is reduced to nitric oxide (NO•) as oxygen tension decreases. Whereas this
pathway modulates hypoxic NO• signaling and mitochondrial respiration and limits …

The present study explored the role of myoglobin (Mb) in cardiac NO homeostasis and its
functional relevance by employing isolated hearts of wild-type (WT) and myoglobin knockout …

The transcription factor signal transducer and activator of transcription 3 (STAT3)
participates in a wide variety of physiological processes and directs seemingly contradictory …