Metabolites produced by the host and microbiota play a crucial role in how human bodies
develop and remain healthy. Most of these metabolites are produced by microbiota and …

Following detection of bacteria, macrophages switch their metabolism from oxidative
respiration through the tricarboxylic acid cycle to high-rate aerobic glycolysis. This …

For decades, lactate has been considered an innocuous bystander metabolite of cellular
metabolism. However, emerging studies show that lactate acts as a complex …

On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium
tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely …

Mitochondria are essential organelles that act as metabolic hubs and signaling platforms
within the cell. Numerous mitochondrial functions, including energy metabolism, lipid …

The finding that the Warburg effect observed in proliferating cancer cells is also observed
during immune responses renewed the interest in the study of metabolic reprogramming of …

Macrophages are important effectors of tissue homeostasis, inflammation and host defense.
They are equipped with an arsenal of pattern recognition receptors (PRRs) necessary to …

Bacterial nutrition is an essential aspect of host–pathogen interaction. For the intracellular
pathogen Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis in humans …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) remains as a leading killer
among infectious diseases worldwide. The nature of the host immune response dictates …

Tuberculosis (TB) is one of the oldest human diseases and is one of the major causes of
mortality and morbidity across the Globe. Mycobacterium tuberculosis (Mtb), the causal …