Latest advancements in the high-throughput single-cell genome (scDNA) and transcriptome
(scRNA) sequencing technologies enabled cell-resolved investigation of tissue clones …

Single-cell multi-omics methods are enabling the study of cell state diversity, which is largely
determined by the interplay of the genome, epigenome, and transcriptome. Here, we …

На основе предложенного ранее подхода синтезом в клетках Escherichia coli получены
гибридные рекомбинантные белки-потенциальные компоненты эпитопных вакцин …

The exogenous application of small peptides can beneficially affect clinical skin appearance
(wrinkles) and architecture (collagen and elastic fibre deposition and epidermal thickness) …

Spatial and genomic heterogeneity of tumors is the key for cancer progression, treatment,
and survival. However, a technology for direct mapping the clones in the tumor tissue based …

Canopy2: A phylogenetic tree can provide insight into a tumor's composition by tracing the
evolutionary lineage of tumor cells as they acquire mutations. We propose Canopy2, a …

The complexity of scRNA-sequencing datasets highlights the urgent need for enhanced
clustering and visualization methods. Here, we propose Stardust, an iterative, force-directed …

Single-cell responses to different cues are crucial for identifying the mechanisms underlying
biological processes to facilitate disease detection and therapeutic development. The …

Whole genome single-cell DNA sequencing (scDNA-seq) enables characterization of copy
number profiles at the cellular level and holds great promise for deciphering tumor …

Cancer is a disease characterized by somatic mutations which accumulate over time and in
response to evolutionary pressures. As a result, tumors are composed of multiple distinct …