The present study investigated the involvement of mediodorsal thalamic (MD) GABA-A
receptors in cetirizine/morphine-induced anti-allodynia using a rat model of neuropathic …

The histamine H 3 receptor is a G protein-coupled receptor (GPCR) drug target that is highly
expressed in the CNS, where it acts as both an auto-and hetero-receptor to regulate …

Background Innocuous cooling of the skin activates cold‐specific Aδ fibres, and hence, the
recording of cold‐evoked potentials (CEPs) may improve the objective assessment of …

Background and Purpose Opioids are effective painkillers. However, their risk–benefit ratio
is dampened by numerous adverse effects and opioid misuse has led to a public health …

Many areas of the brain along with neurotransmitters involve in processing of nociceptive,
emotional and cognitive dimensions of neuropathic pain. Brian neuronal histamine through …

Sodium oxybate (SO) has been in use for many decades to treat narcolepsy with cataplexy.
It functions as a weak GABAB agonist but also as an energy source for the brain as a result …

Itch and pain are closely related but distinct sensations that share largely overlapping
mediators and receptors. We hypothesized that the novel, multi-target compound E153 has …

With the recent market approval of Pitolisant (Wakix®), the interest in clinical application for
novel multifunctional histamine H3 receptor antagonists has clearly increased. Several …

The synthesis and H 3 receptor ligand of a new series of lactam derivatives are reported.
The new compounds were evaluated in vitro in H 3 and H 1 receptor-binding assays. The …

There is a huge need for pharmaceutical agents for the treatment of chronic Neuropathic
Pain (NP), a complex condition where patients can suffer from either hyperalgesia or …