Clinical course and prediction of survival in idiopathic pulmonary fibrosis

B Ley, HR Collard, TE King Jr - American journal of respiratory and …, 2011 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, life-threatening, interstitial lung disease
of unknown etiology. The median survival of patients with IPF is only 2 to 3 years, yet some …

Idiopathic pulmonary fibrosis

TE King, A Pardo, M Selman - The Lancet, 2011 - thelancet.com
Idiopathic pulmonary fibrosis is a devastating, age-related lung disease of unknown cause
that has few treatment options. This disease was once thought to be a chronic inflammatory …

Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis. an integral model

M Selman, A Pardo - American journal of respiratory and critical …, 2014 - atsjournals.org
A growing body of evidence indicates that aberrant activation of alveolar epithelial cells and
fibroblasts in an aging lung plays a critical role in the pathogenesis of idiopathic pulmonary …

Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis

AL Peljto, Y Zhang, TE Fingerlin, SF Ma, JGN Garcia… - Jama, 2013 - jamanetwork.com
Importance Current prediction models of mortality in idiopathic pulmonary fibrosis (IPF),
which are based on clinical and physiological parameters, have modest value in predicting …

Antifibrotic activities of pirfenidone in animal models

CJ Schaefer, DW Ruhrmund, L Pan… - European …, 2011 - Eur Respiratory Soc
Pirfenidone is an orally active small molecule that has recently been evaluated in large
clinical trials for the treatment of idiopathic pulmonary fibrosis, a fatal disease in which the …

Idiopathic pulmonary fibrosis: diagnosis, epidemiology and natural history

G Sgalla, A Biffi, L Richeldi - Respirology, 2016 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing lung disorder of
unknown aetiology whose diagnosis involves the careful exclusion of secondary causes for …

MicroRNAs in idiopathic pulmonary fibrosis

KV Pandit, J Milosevic, N Kaminski - Translational research, 2011 - Elsevier
In this review, we describe the recent advances in the understanding of the role of
microRNAs in idiopathic pulmonary fibrosis (IPF), a chronic progressive and lethal fibrotic …

[HTML][HTML] Molecular biomarkers in idiopathic pulmonary fibrosis: state of the art and future directions

A Stainer, P Faverio, S Busnelli, M Catalano… - International Journal of …, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF), the most lethal form of interstitial pneumonia of unknown
cause, is associated with a specific radiological and histopathological pattern (the so-called …

Strategies for treating idiopathic pulmonary fibrosis

RM Du Bois - Nature reviews Drug discovery, 2010 - nature.com
Idiopathic pulmonary fibrosis (IPF) is the most common and most lethal diffuse fibrosing lung
disease, with a mortality rate that exceeds that of many cancers. Recently, there have been …

Molecular biomarkers in idiopathic pulmonary fibrosis

B Ley, KK Brown, HR Collard - American Journal of …, 2014 - journals.physiology.org
Molecular biomarkers are highly desired in idiopathic pulmonary fibrosis (IPF), where they
hold the potential to elucidate underlying disease mechanisms, accelerated drug …