Regulation of effector and memory CD8 T cell differentiation by IL-2—a balancing act
Interleukin-2 (IL-2) regulates key aspects of CD8 T cell biology–signaling through distinct
pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum …
pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum …
Overview of traumatic brain injury: an immunological context
D Nizamutdinov, LA Shapiro - Brain sciences, 2017 - mdpi.com
Traumatic brain injury (TBI) afflicts people of all ages and genders, and the severity of injury
ranges from concussion/mild TBI to severe TBI. Across all spectrums, TBI has wide-ranging …
ranges from concussion/mild TBI to severe TBI. Across all spectrums, TBI has wide-ranging …
Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection
JM Angelosanto, SD Blackburn, A Crawford… - Journal of …, 2012 - Am Soc Microbiol
ABSTRACT T cell exhaustion and loss of memory potential occur during many chronic viral
infections and cancer. We investigated when during chronic viral infection virus-specific CD8 …
infections and cancer. We investigated when during chronic viral infection virus-specific CD8 …
Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice
Inhibitory signaling in dysfunctional CD8 T cells through the programmed cell death 1 (PD-1)
axis is well established in chronic viral infections and cancers. PD-1 is also transiently …
axis is well established in chronic viral infections and cancers. PD-1 is also transiently …
Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity
C Liu, A Somasundaram, S Manne, AM Gocher… - Nature …, 2020 - nature.com
Robust CD8+ T cell memory is essential for long-term protective immunity but is often
compromised in cancer, where T cell exhaustion leads to loss of memory precursors …
compromised in cancer, where T cell exhaustion leads to loss of memory precursors …
Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV
P Fisicaro, C Valdatta, M Massari, E Loggi, L Ravanetti… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: In patients with chronic hepatitis B virus (HBV) and hepatitis C virus
(HCV) infections, antiviral functions of T cells are impaired; these might be increased by …
(HCV) infections, antiviral functions of T cells are impaired; these might be increased by …
Immune response of T cells during herpes simplex virus type 1 (HSV-1) infection
J Zhang, H Liu, B Wei - Journal of Zhejiang University-Science B, 2017 - Springer
Herpes simplex virus type 1 (HSV-1), a neurotropic member of the alphaherpes virus family,
is among the most prevalent and successful human pathogens. HSV-1 can cause serious …
is among the most prevalent and successful human pathogens. HSV-1 can cause serious …
Stem memory T cells (TSCM)—their role in cancer and HIV immunotherapies
JK Flynn, PR Gorry - Clinical & translational immunology, 2014 - Wiley Online Library
Stem memory T cells (TSCM) have been described in mice, non‐human primates and in
humans, constituting approximately 2–4% of the total CD4+ and CD8+ T‐cell population in …
humans, constituting approximately 2–4% of the total CD4+ and CD8+ T‐cell population in …
[HTML][HTML] Quiescence of memory CD8+ T cells is mediated by regulatory T cells through inhibitory receptor CTLA-4
V Kalia, LA Penny, Y Yuzefpolskiy, FM Baumann… - Immunity, 2015 - cell.com
Immune memory cells are poised to rapidly expand and elaborate effector functions upon
reinfection yet exist in a functionally quiescent state. The paradigm is that memory T cells …
reinfection yet exist in a functionally quiescent state. The paradigm is that memory T cells …
MicroRNA-17∼ 92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections
AA Khan, LA Penny, Y Yuzefpolskiy… - Blood, The Journal …, 2013 - ashpublications.org
The precise microRNAs and their target cellular processes involved in generation of durable
T-cell immunity remain undefined. Here we show a dynamic regulation of microRNAs as …
T-cell immunity remain undefined. Here we show a dynamic regulation of microRNAs as …