The pharmacokinetics and pharmacodynamics of drugs are different in adult and paediatric
populations, the latter being particularly heterogeneous. These differences in …

Sepsis remains a major cause of mortality and morbidity in neonates, and, as a
consequence, antibiotics are the most frequently prescribed drugs in this vulnerable patient …

Kucers' The Use of Antibiotics is the definitive, internationally-authored reference, providing
everything that the infectious diseases specialist and prescriber needs to know about …

Neonatal Infections are among the most common reasons for admission to the intensive
care unit. Neonatal sepsis (NS) significantly contributes to mortality rates. Empiric antibiotic …

The volume of distribution at steady state (Vss) in neonates is still often estimated through
isometric scaling from adult values, disregarding developmental changes beyond body …

Three decades after its introduction, pharmacokinetic population approaches have become
a reference method for drug modelling, particularly in paediatrics. The main practical …

Abstract Background and Objective In neonates, β-Lactam antibiotics are almost exclusively
administered by intermittent infusion. However, continuous or prolonged infusion may be …

Pharmacokinetic/pharmacodynamic (PKPD) modelling is used to describe and quantify
dose–concentration–effect relationships. Within paediatric studies in infectious diseases and …

Objectives Cefazolin is frequently administered for antimicrobial prophylaxis and treatment
of infections. In neonates, pharmacokinetic observations are limited and dosing regimens …

Infants are therapeutic orphans. Many drugs used in infants are used “off-label”, increasing
the risk of drug toxicity and suboptimal efficacy in this vulnerable population. This knowledge …