Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

Background As common, progressive, and chronic causes of disability and death,
neurodegenerative diseases (NDDs) significantly threaten human health, while no effective …

When faced with increased workload the heart undergoes remodelling, where it increases
its muscle mass in an attempt to preserve normal function. This is referred to as cardiac …

Lipopolysaccharide (LPS) from Gram-negative bacteria is a major contributor to
cardiovascular failure, but the signaling mechanisms underlying its stress response are not …

Mounting studies have substantiated that abrogating autophagy contributes to cardiac
hypertrophy (CH). Sirtuin 1 (SIRT1) has been reported to support autophagy and inhibit CH …

Chlorpyrifos (CPF), a widely used organophosphate pesticide that has caused large-scale
contamination globally, has become a major concern. Baicalein (BAI), as a flavonoid extract …

Oxidative damage and accumulation of extracellular matrix (ECM) components play a
crucial role in the adverse outcome of cardiac hypertrophy. Evidence suggests that nuclear …

Cardiac hypertrophy, a stereotypic cardiac response to increased workload, ultimately
progresses to severe contractile dysfunction and uncompensated heart failure without …

Low back pain is a major cause of disability worldwide that declines the quality of life; it
poses a substantial economic burden for the patient and society. Intervertebral disc (IVD) …

Mitochondrial autophagy (or mitophagy) regulates the mitochondrial network and function to
contribute to multiple cellular processes. The protective effect of homeostatic mitophagy in …