Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation

CW Shields Iv, CD Reyes, GP López - Lab on a Chip, 2015 - pubs.rsc.org
Accurate and high throughput cell sorting is a critical enabling technology in molecular and
cellular biology, biotechnology, and medicine. While conventional methods can provide high …

Microfluidic‐based approaches in targeted cell/particle separation based on physical properties: fundamentals and applications

R Nasiri, A Shamloo, S Ahadian, L Amirifar, J Akbari… - Small, 2020 - Wiley Online Library
Cell separation is a key step in many biomedical research areas including biotechnology,
cancer research, regenerative medicine, and drug discovery. While conventional cell sorting …

[HTML][HTML] Isolation and retrieval of circulating tumor cells using centrifugal forces

HW Hou, ME Warkiani, BL Khoo, ZR Li, RA Soo… - Scientific reports, 2013 - nature.com
Presence and frequency of rare circulating tumor cells (CTCs) in bloodstreams of cancer
patients are pivotal to early cancer detection and treatment monitoring. Here, we use a spiral …

[HTML][HTML] Microfluidic paper-based analytical devices (μPADs) and micro total analysis systems (μTAS): Development, applications and future trends

P Lisowski, PK Zarzycki - Chromatographia, 2013 - Springer
Microfluidic paper-based analytical devices and micro total analysis systems are relatively
new group of analytical tools, capable of analyzing complex biochemical samples …

Separation of leukocytes from blood using spiral channel with trapezoid cross-section

L Wu, G Guan, HW Hou, AAS Bhagat, J Han - Analytical chemistry, 2012 - ACS Publications
Inertial microfluidics has recently drawn wide attention as an efficient, high-throughput
microfluidic cell separation method. However, the achieved separation resolution and …

[HTML][HTML] Rotational separation of non-spherical bioparticles using I-shaped pillar arrays in a microfluidic device

KK Zeming, S Ranjan, Y Zhang - Nature communications, 2013 - nature.com
Most bioparticles, such as red blood cells and bacteria, are non-spherical in shape.
However, conventional microfluidic separation devices are designed for spherical particles …

Passive blood plasma separation at the microscale: A review of design principles and microdevices

S Tripathi, YVBV Kumar, A Prabhakar… - Journal of …, 2015 - iopscience.iop.org
Blood plasma separation is vital in the field of diagnostics and health care. Due to the
inherent advantages obtained in the transition to microscale, the recent trend in these fields …

Microfluidics for label-free sorting of rare circulating tumor cells

S Zhu, F Jiang, Y Han, N Xiang, Z Ni - Analyst, 2020 - pubs.rsc.org
Circulating tumor cells (CTCs) have been widely considered as promising novel biomarkers
for molecular research and clinical diagnosis of cancer. However, the sorting of CTCs is very …

Microfluidic blood cell sorting: now and beyond

ZTF Yu, KM Aw Yong, J Fu - Small, 2014 - Wiley Online Library
Blood plays an important role in homeostatic regulation with each of its cellular components
having important therapeutic and diagnostic uses. Therefore, separation and sorting of …

Isoporous micro/nanoengineered membranes

ME Warkiani, AAS Bhagat, BL Khoo, J Han, CT Lim… - ACS …, 2013 - ACS Publications
Isoporous membranes are versatile structures with numerous potential and realized
applications in various fields of science such as micro/nanofiltration, cell separation and …