N-type calcium channels modulate the release of key pro-nociceptive neurotransmitters
such as glutamate and substance P (SP) in the central nervous system. Considerable …

Diabetic neuropathy accompanied by anomalies in pain perception is one of the most
frequent complications in insulin-dependent diabetes in humans. Many clinical and …

Schmerz ist genauso wie Hunger und Durst ein Urphänomen des Lebens. Während dem
akuten Schmerz eine durchaus sinnvolle und lebenserhaltende Funktion zukommt, fehlt …

The stimulation of C-fiber sensory neurons is known to induce activation of the ERK MAP
kinase signaling pathway in the spinal cord dorsal horn. In this study we have elucidated …

We examined the tail-flick response to various heat intensities in diabetic and non-diabetic
mice. Heat intensities were set to one of five values by adjusting the source voltage of a 50 …

Capsaicin stimulates neurokinin release in the spinal cord when applied both centrally and
peripherally. To determine whether these two actions have different mechanisms, we …

Previous studies have shown that substance P (SP) may modulate the abstinence reaction
to opioid withdrawal. Its N-terminal fragment SP1–7 may inhibit the intensity of the …

Capsaicin depolarizes primary afferent C-fibers releasing substance P (SP) whose N-
terminal metabolites appear to play a role in the development of antinociception. Because …

We examined the involvement of cytosolic calcium on thermal hyperalgesia and allodynia
seen in diabetic mice. Tail-flick latencies at source voltages of a 50-W projection bulb to 35 …

The N-terminal metabolite of the undecapeptide substance P (SP), substance P1–7 (SP1–
7), is known to modulate nociception in the central nervous system (CNS) and often has …