The whole‐body (tachymetabolic) endothermy seen in modern birds and mammals is long
held to have evolved independently in each group, a reasonable assumption when it was …

Avian cold adaptation is hallmarked by innovative strategies of both heat conservation and
thermogenesis. While minimizing heat loss can reduce the thermogenic demands of body …

Objective Classical ATP-independent non-shivering thermogenesis enabled by uncoupling
protein 1 (UCP1) in brown adipose tissue (BAT) is activated, but not essential for survival, in …

Endothermy underpins the ecological dominance of mammals and birds in diverse
environmental settings 1, 2. However, it is unclear when this crucial feature emerged during …

Endothermy, ie the endogenous production of metabolic heat, has evolved multiple times
among vertebrates, and several strategies of heat production have been studied extensively …

Abstract Chronic Fatigue Syndrome or Myalgic Encephaloymelitis (ME/CFS) is a frequent
debilitating disease with an enigmatic etiology. The finding of autoantibodies against ß2 …

The sarco/endoplasmic reticulum Ca-ATPase (SERCA) is a P-type ion pump that transports
Ca2+ from the cytosol into the endoplasmic/sarcoplasmic reticulum (ER/SR) in most …

Adipose tissue is a recognized energy storage organ during excessive energy intake and an
endocrine and thermoregulator, which interacts with other tissues to regulate systemic …

Obesity is a chronic disease derived from disequilibrium between energy intake and energy
expenditure and evolving as a challenging epidemiological disease in the 21st century. It is …

We have used FRET-based biosensors in live cells, in a robust high-throughput screening
(HTS) platform, to identify small-molecules that alter the structure and activity of the cardiac …