Bilirubin is the end product of heme catabolism formed during a process that involves
oxidation-reduction reactions and conserves iron body stores. Unconjugated …

Bilirubin-induced neurological damage (BIND) has been a subject of studies for decades,
yet the molecular mechanisms at the core of this damage remain largely unknown …

Hereditary hemolytic anemia (HHA) is a group of genetically and phenotypically
heterogeneous disorders characterized by premature destruction of red blood cells (RBC s) …

Dopamine is a well-known neurotransmitter due to its involvement in Parkinson's disease
(PD). Dopamine is not only involved in PD but also controls multiple mental and physical …

Simple Summary Severe neonatal hyperbilirubinemia may damage the brain, leading to
motor, cognitive, and auditory abnormalities. We recently discovered that bilirubin might act …

Background Accumulation of bilirubin above normal levels is considered a neurological risk
factor for both premature and full‐term newborns. This systematic review aimed to determine …

Objective Jaundice (icterus) is the visible manifestation of the accumulation of bilirubin in the
tissue and is indicative of potential toxicity to the brain. Since its very first description more …

Background Severe neonatal jaundice resulting from elevated levels of unconjugated
bilirubin in the blood induces dramatic neurological impairment. Central oxidative stress and …

Cellular redox status has a crucial role in brain physiology, as well as in pathologic
conditions. Physiologic senescence, by dysregulating cellular redox homeostasis and …

Insufficient milk intake in breastfed neonates is common, frequently missed, and causes
preventable hospitalizations for jaundice/hyperbilirubinemia, hypernatremia/dehydration …