[HTML][HTML] Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification

AJ Seukep, V Kuete, L Nahar, SD Sarker… - Journal of pharmaceutical …, 2020 - Elsevier
The upsurge of multiple drug resistance (MDR) bacteria substantially diminishes the
effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic failure. The …

Antibiotics: Pharmacokinetics, toxicity, resistance and multidrug efflux pumps

Ç Yılmaz, G Özcengiz - Biochemical pharmacology, 2017 - Elsevier
The discovery of penicillin followed by streptomycin, tetracycline, cephalosporins and other
natural, semi-synthetic and synthetic antimicrobials completely revolutionized medicine by …

Role of medicinal plants from North Western Himalayas as an efflux pump inhibitor against MDR AcrAB-TolC Salmonella enterica serovar typhimurium: In vitro and In …

J Mehta, R Rolta, K Dev - Journal of Ethnopharmacology, 2022 - Elsevier
Abstract Ethnopharmacological relevance Zingiber officinale Roscoe has been utilized
traditionally to cure various diseases like cold, cough, diarrhoea, nausea, asthma, vomiting …

[HTML][HTML] Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development

A Parthasarathy, EJ Borrego, MA Savka… - Journal of Biological …, 2021 - ASBMB
For millennia, humanity has relied on plants for its medicines, and modern pharmacology
continues to reexamine and mine plant metabolites for novel compounds and to guide …

[HTML][HTML] The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy

A Avakh, GD Grant, MJ Cheesman, T Kalkundri, S Hall - Antibiotics, 2023 - mdpi.com
Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …

RND efflux pump mediated antibiotic resistance in Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa: a major issue worldwide

M Puzari, P Chetia - World Journal of Microbiology and Biotechnology, 2017 - Springer
Therapeutic failures against diseases due to resistant Gram-negative bacteria have become
a major threat nowadays as confirmed by surveillance reports across the world. One of the …

[PDF][PDF] Antimicrobial compounds of plant origin as efflux pump inhibitors: new avenues for controlling multidrug resistant pathogens

M Rao, S Padyana, KM Dipin, S Kumar… - J. Antimicrob …, 2018 - academia.edu
The emergence of multiple drug resistant pathogenic bacteria has severely constricted the
antimicrobial options of treating infectious diseases. One of the powerful mechanisms of …

Effect of piperine on the inhibitory potential of MexAB-OprM efflux pump and imipenem resistance in carbapenem-resistant Pseudomonas aeruginosa

Y Liu, R Zhu, X Liu, D Li, M Guo, B Fei, Y Ren… - Microbial …, 2023 - Elsevier
The escalating prevalence of carbapenem-resistant Pseudomonas aeruginosa (CRPA)
poses a significant threat to global public health through the spread of its 'high-risk'clones …

Do phenothiazines possess antimicrobial and efflux inhibitory properties?

EM Grimsey, LJV Piddock - FEMS Microbiology Reviews, 2019 - academic.oup.com
Antibiotic resistance is a global health concern; the rise of drug-resistant bacterial infections
is compromising the medical advances that resulted from the introduction of antibiotics at the …

Non-antibiotic antimicrobial interventions and antimicrobial stewardship in wound care

R Cooper, K Kirketerp-Møller - Journal of wound care, 2018 - magonlinelibrary.com
Control of wound infection today relies largely on antibiotics, but the continual emergence of
antibiotic-resistant microorganisms threatens a return to the pre-antibiotic era when …