Bacteria belonging to the genus Streptococcus are the first inhabitants of the oral cavity,
which can be acquired right after birth and thus play an important role in the assembly of the …

Microbiota are now widely recognized as being central players in the health of all organisms
and ecosystems, and subsequently have been the subject of intense study. However …

The oral microbiome plays key roles in human biology, health, and disease, but little is
known about the global diversity, variation, or evolution of this microbial community. To …

RNA-guided DNA endonucleases of the CRISPR-Cas system are widely used for genome
engineering and thus have numerous applications in a wide variety of fields. CRISPR …

Oral commensal streptococci are primary colonizers of the oral cavity. These streptococci
produce many adhesins, metabolites, and antimicrobials that modulate microbial succession …

Abstract CRISPR-associated (Cas) DNA-endonucleases are remarkably effective tools for
genome engineering, but have limited target ranges due to their protospacer adjacent motif …

The massive accumulation of genome-sequences in public databases promoted the
proliferation of genome-level phylogenetic analyses in many areas of biological research …

Background Genomes of bacteria and archaea (collectively, prokaryotes) appear to exist in
incessant flux, expanding via horizontal gene transfer and gene duplication, and contracting …

The oral cavity is suggested as the reservoir of bacterial infection, and the oral and
pharyngeal biofilms formed by oral bacterial flora, which is comprised of over 700 microbial …

The mitis group of streptococci comprises species that are common colonizers of the naso-
oral-pharyngeal tract of humans. Streptococcus pneumoniae and Streptococcus mitis are …