Intestinal inflammatory diseases, such as Crohn's disease, ulcerative colitis, and necrotizing
enterocolitis, are becoming increasingly prevalent. While knowledge of the pathogenesis of …

The chronic inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are
recognized as important causes of gastrointestinal disease in children and adults. In this …

Obesity-induced colonic inflammation-stimulated colitis is one of the main causes of
colorectal cancer. Dietary polysaccharides are considered an effective agent for relieving …

The cytokine interleukin-10 (IL-10) has shown promise in clinical trials for treatment of
inflammatory bowel disease (IBD). Using two mouse models, we show that the therapeutic …

Azathioprine and its metabolite 6-mercaptopurine (6-MP) are immunosuppressive drugs that
are used in organ transplantation and autoimmune and chronic inflammatory diseases such …

Background and aims: Ulcerative colitis (UC) is an acute and chronic inflammatory disease
of the large bowel with unknown aetiology. The immune response against normal …

The intestinal microbiota is the largest source of microbial stimulation that exerts both
harmful and beneficial effects on human health. The interaction between probiotic and …

Abbreviations: Apaf, apoptosis protease activation factor; CAD, caspase-activated DNAse;
caspase, cysteine aspartate-directed protease; CAPK, ceramide-activated protein kinase; …

Background & Aims: Previous studies have linked Crohn's disease (CD) to the
pericentromeric region of chromosome 16 (IBD1). Three independent studies of Western …

The gastrointestinal (GI) tract is a complex ecosystem generated by the alliance of GI
epithelium, immune cells and resident microbiota. The three components of the GI …