Prolactinomas account for approximately 40% of all pituitary adenomas and are an
important cause of hypogonadism and infertility. The ultimate goal of therapy for …

Abstract Prolactin (PRL) is a 23-kDa protein hormone that binds to a single-span membrane
receptor, a member of the cytokine receptor superfamily, and exerts its action via several …

Migraine is a severe neurovascular disorder of which the pathophysiology is not yet fully
understood. Besides the role of inflammatory mediators that interact with the …

Hyperprolactinemia is one of the most frequently diagnosed clinical disorders in routine
endocrine practice. Any process interfering with dopamine synthesis, its transport to the …

Prolactin and the prolactin receptors are members of a family of hormone/receptor pairs
which include GH, erythropoietin, and other ligand/receptor pairs. The mechanisms of these …

Prolactinomas, the most prevalent type of neuroendocrine disease, account for
approximately 40% of all pituitary adenomas. The most important clinical problems …

Purpose Epidemiologic studies suggest that prolactin is associated with breast cancer risk in
older women. Because of limited prospective data, particularly in younger women, we …

Resistance to chemotherapy is a major complication in the treatment of advanced breast
cancer. Estrogens and prolactin (PRL) are implicated in the pathogenesis of breast cancer …

Prolactin has a rich mechanistic set of actions and signaling in order to elicit developmental
effects in mammals. Historically, prolactin has been appreciated as an endocrine peptide …

Background Giant prolactinomas are an unusual subset of macroprolactinomas and are
more commonly found in men. The goal of this review is to propose a giant prolactinoma …