Molecular simulations of amyloid beta assemblies

G Grasso, A Danani - Advances in Physics: X, 2020 - Taylor & Francis
Several neurodegenerative disorders arise from the abnormal protein aggregation in the
nervous tissue leading tointracellular inclusions or extracellular aggregates in specific brain …

Green Tea Extracts EGCG and EGC Display Distinct Mechanisms in Disrupting Aβ42 Protofibril

C Zhan, Y Chen, Y Tang, G Wei - ACS chemical neuroscience, 2020 - ACS Publications
The amyloid beta (Aβ) fibrillar aggregate is the hallmark of Alzheimer's disease (AD).
Disassembling preformed fibril or inhibiting Aβ aggregation is considered as a therapeutic …

[HTML][HTML] WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis

P Tai, X Chen, G Jia, G Chen, L Gong, Y Cheng… - Journal of translational …, 2023 - Springer
Background Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its
clinical application. It is indispensable to explore alternative treatment molecules or drugs for …

A comprehensive insight into the mechanisms of dopamine in disrupting Aβ protofibrils and inhibiting Aβ aggregation

Y Chen, X Li, C Zhan, Z Lao, F Li… - ACS Chemical …, 2021 - ACS Publications
Fibrillary aggregates of amyloid-β (Aβ) are the pathological hallmark of Alzheimer's disease
(AD). Clearing Aβ deposition or inhibiting Aβ aggregation is a promising approach to treat …

Multiple effects of spicy flavors on neurological diseases through the intervention of TRPV1: a critical review

B Hu, H Wang, H Liang, N Ma, D Wu… - Critical Reviews in …, 2024 - Taylor & Francis
The spicy properties of foods are contributed by various spicy flavor substances (SFs) such
as capsaicin, piperine, and allicin. Beyond their distinctive sensory characteristics, SFs also …

[HTML][HTML] Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain

A Amano, N Sanjo, W Araki, Y Anraku… - Journal of …, 2023 - Springer
Background Although a large amount of evidence has revealed that amyloid β (Aβ),
especially Aβ oligomers, protofibrils, and pyroglutamated Aβs, participate primarily in the …

Serotonin and Melatonin Show Different Modes of Action on Aβ42 Protofibril Destabilization

Y Gong, C Zhan, Y Zou, Z Qian, G Wei… - ACS Chemical …, 2021 - ACS Publications
Alzheimer's disease (AD) is associated with the aberrant self-assembly of amyloid-β (Aβ)
protein into fibrillar deposits. The disaggregation of Aβ fibril is believed as one of the major …

Mechanistic insights into the mitigation of Aβ aggregation and protofibril destabilization by ad-enantiomeric decapeptide rk10

K Singh, A Kaur, D Goyal, B Goyal - Physical Chemistry Chemical …, 2022 - pubs.rsc.org
According to clinical studies, the development of Alzheimer's disease (AD) is linked to the
abnormal aggregation of amyloid-β (Aβ) peptides into toxic soluble oligomers, protofibrils as …

Multiepitope subunit vaccine to evoke immune response against acute encephalitis

N Kumar, D Sood, N Sharma… - Journal of Chemical …, 2019 - ACS Publications
Acute encephalitis syndrome outbreak has emerged as a major health concern on both
national and international scales. Brain inflammation/infections caused by Japanese …

Comparative binding analysis of WGX50 and Alpha-M with APP family proteins APLP1 and APLP2 using structural-dynamics and free energy calculation approaches

A Ali, A Masood, AA Khan, FY Zhu… - Physical Chemistry …, 2023 - pubs.rsc.org
AD is a common disease among other neurodegenerative disorders primarily developing
due to amyloid-β (Aβ) neurotoxicity derived from the amyloid-β protein precursor (AβPP) …