Molecular simulations of amyloid beta assemblies
G Grasso, A Danani - Advances in Physics: X, 2020 - Taylor & Francis
Several neurodegenerative disorders arise from the abnormal protein aggregation in the
nervous tissue leading tointracellular inclusions or extracellular aggregates in specific brain …
nervous tissue leading tointracellular inclusions or extracellular aggregates in specific brain …
Green Tea Extracts EGCG and EGC Display Distinct Mechanisms in Disrupting Aβ42 Protofibril
The amyloid beta (Aβ) fibrillar aggregate is the hallmark of Alzheimer's disease (AD).
Disassembling preformed fibril or inhibiting Aβ aggregation is considered as a therapeutic …
Disassembling preformed fibril or inhibiting Aβ aggregation is considered as a therapeutic …
[HTML][HTML] WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis
P Tai, X Chen, G Jia, G Chen, L Gong, Y Cheng… - Journal of translational …, 2023 - Springer
Background Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its
clinical application. It is indispensable to explore alternative treatment molecules or drugs for …
clinical application. It is indispensable to explore alternative treatment molecules or drugs for …
A comprehensive insight into the mechanisms of dopamine in disrupting Aβ protofibrils and inhibiting Aβ aggregation
Fibrillary aggregates of amyloid-β (Aβ) are the pathological hallmark of Alzheimer's disease
(AD). Clearing Aβ deposition or inhibiting Aβ aggregation is a promising approach to treat …
(AD). Clearing Aβ deposition or inhibiting Aβ aggregation is a promising approach to treat …
Multiple effects of spicy flavors on neurological diseases through the intervention of TRPV1: a critical review
B Hu, H Wang, H Liang, N Ma, D Wu… - Critical Reviews in …, 2024 - Taylor & Francis
The spicy properties of foods are contributed by various spicy flavor substances (SFs) such
as capsaicin, piperine, and allicin. Beyond their distinctive sensory characteristics, SFs also …
as capsaicin, piperine, and allicin. Beyond their distinctive sensory characteristics, SFs also …
[HTML][HTML] Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain
A Amano, N Sanjo, W Araki, Y Anraku… - Journal of …, 2023 - Springer
Background Although a large amount of evidence has revealed that amyloid β (Aβ),
especially Aβ oligomers, protofibrils, and pyroglutamated Aβs, participate primarily in the …
especially Aβ oligomers, protofibrils, and pyroglutamated Aβs, participate primarily in the …
Serotonin and Melatonin Show Different Modes of Action on Aβ42 Protofibril Destabilization
Alzheimer's disease (AD) is associated with the aberrant self-assembly of amyloid-β (Aβ)
protein into fibrillar deposits. The disaggregation of Aβ fibril is believed as one of the major …
protein into fibrillar deposits. The disaggregation of Aβ fibril is believed as one of the major …
Mechanistic insights into the mitigation of Aβ aggregation and protofibril destabilization by ad-enantiomeric decapeptide rk10
According to clinical studies, the development of Alzheimer's disease (AD) is linked to the
abnormal aggregation of amyloid-β (Aβ) peptides into toxic soluble oligomers, protofibrils as …
abnormal aggregation of amyloid-β (Aβ) peptides into toxic soluble oligomers, protofibrils as …
Multiepitope subunit vaccine to evoke immune response against acute encephalitis
Acute encephalitis syndrome outbreak has emerged as a major health concern on both
national and international scales. Brain inflammation/infections caused by Japanese …
national and international scales. Brain inflammation/infections caused by Japanese …
Comparative binding analysis of WGX50 and Alpha-M with APP family proteins APLP1 and APLP2 using structural-dynamics and free energy calculation approaches
AD is a common disease among other neurodegenerative disorders primarily developing
due to amyloid-β (Aβ) neurotoxicity derived from the amyloid-β protein precursor (AβPP) …
due to amyloid-β (Aβ) neurotoxicity derived from the amyloid-β protein precursor (AβPP) …