Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

The skin, acting as the outer protection of the human body, is most vulnerable to injury.
Wound healing can often be impaired, leading to chronic, hard-to-heal wounds. For this …

Biofilm‐infected diabetic wounds (BIDWs) with hyperglycemia and bacterial colonization are
characterized by disordered inflammation and abnormal activation of NLRP3 …

Background The complicated hyperglycaemic and chronic inflammation of diabetic wounds
in orthopaedic surgery leads to dysregulated immune cell function and potential infection …

Wound healing, a highly complex pathophysiological response to injury, includes four
overlapping phases of hemostasis, inflammation, proliferation, and remodeling. Initiation …

Diabetic wound is one of the complications of diabetes and is not easy to heal. It often
evolves into chronic ulcers, and severe patients will face amputation. Compared with normal …

The immune microenvironment plays a critical role in regulating skin wound healing.
Macrophages, the main component of infiltrating inflammatory cells, play a pivotal role in …

Wound healing is a major secondary complication in type 2 diabetes, which results in
significant disability and mortality, imposing a significant clinical and social burden …

It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic
dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is …

Moderate inflammation is essential for standard wound healing. In pathological conditions,
such as diabetes, protracted and refractory wounds are associated with excessive …