Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

Pulmonary arterial hypertension (PAH) is a devastating disease that involves pulmonary
vasoconstriction, small vessel obliteration, large vessel thickening and obstruction, and …

Pulmonary arterial hypertension (PAH) is a rare, complex, and progressive disease that is
characterized by the abnormal remodeling of the pulmonary arteries that leads to right …

Aims Endothelial cell (EC) dysfunction drives the initiation and pathogenesis of pulmonary
arterial hypertension (PAH). We aimed to characterize EC dynamics in PAH at single-cell …

The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …

Pulmonary arterial hypertension (PAH) is clinically characterized by a progressive increase
in pulmonary artery pressure, followed by right ventricular hypertrophy and subsequently …

Background Pyroptosis is a form of programmed cell death involved in the
pathophysiological progression of hypoxic pulmonary hypertension (HPH). Emerging …

Pulmonary hypertension (PH) describes a group of severe pulmonary vascular disorders
characterized by elevated mean pulmonary arterial pressure (mPAP) at rest. 1 The World …

Background: Pulmonary arterial hypertension (PAH) is a life-threatening disorder of the
pulmonary circulation associated with loss and impaired regeneration of microvessels …

An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …