Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteria

Q Gao, S Lu, Y Wang, L He, M Wang, R Jia… - Frontiers in …, 2023 - frontiersin.org
Epigenetics modulates expression levels of various important genes in both prokaryotes and
eukaryotes. These epigenetic traits are heritable without any change in genetic DNA …

Species Delineation and Comparative Genomics within the Campylobacter ureolyticus Complex

JJ Maki, M Howard, S Connelly… - Journal of Clinical …, 2023 - Am Soc Microbiol
Campylobacter ureolyticus is an emerging pathogen increasingly appreciated as a common
cause of gastroenteritis and extra-intestinal infections in humans. Outside the setting of …

Long‐Read Sequencing Reveals Extensive DNA Methylations in Human Gut Phagenome Contributed by Prevalently Phage‐Encoded Methyltransferases

C Sun, J Chen, M Jin, X Zhao, Y Li, Y Dong… - Advanced …, 2023 - Wiley Online Library
DNA methylation plays a crucial role in the survival of bacteriophages (phages), yet the
understanding of their genome methylation remains limited. In this study, DNA methylation …

Comparative genomics and DNA methylation analysis of Pseudomonas aeruginosa clinical isolate PA3 by single-molecule real-time sequencing reveals new targets …

Z Li, X Zhou, D Liao, R Liu, X Zhao, J Wang… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Pseudomonas aeruginosa (P. aeruginosa) is an important opportunistic
pathogen with broad environmental adaptability and complex drug resistance. Single …

AamA-mediated epigenetic control of genome-wide gene expression and phenotypic traits in Acinetobacter baumannii ATCC 17978

J Yang, Y Son, M Kang, W Park - Microbial genomics, 2023 - microbiologyresearch.org
Individual deletions of three genes encoding orphan DNA methyltransferases resulted in the
occurrence of growth defect only in the aamA (encoding A cinetobacter A denine M ethylase …

Extension of bacterial rDNA sequencing for simultaneous methylation detection and its application in microflora analysis

M Nishimura, T Tanaka, S Murata, A Miyabe… - Scientific Reports, 2023 - nature.com
Although polymerase chain reaction (PCR) amplification and sequencing of the bacterial
16S rDNA region has numerous scientific applications, it does not provide DNA methylation …

Bacmethy: A novel and convenient tool for investigating bacterial DNA methylation pattern and their transcriptional regulation effects

JH Liu, Y Zhang, N Zhou, J He, J Xu, Z Cai, L Yang… - iMeta, 2024 - Wiley Online Library
DNA methylation serves as the primary mode of epigenetic regulation in prokaryotes,
particularly through transcriptional regulation. With the rapid implementation of third …

[HTML][HTML] Identification of anti-pathogenic activity among in silico predicted small-molecule inhibitors of Pseudomonas aeruginosa LasR or nitric oxide reductase (NOR)

G Gajera, N Henriksen, B Cox, V Kothari - Drug Target Insights, 2023 - ncbi.nlm.nih.gov
Methods: In silico identification of potential LasR or NOR inhibitors was attempted through a
virtual screening platform AtomNet® to obtain a final subset of< 100 top scoring compounds …

Developing new tools to fight human pathogens: A journey through the advances in RNA technologies

VG Costa, SM Costa, M Saramago, MV Cunha… - Microorganisms, 2022 - mdpi.com
A long scientific journey has led to prominent technological advances in the RNA field, and
several new types of molecules have been discovered, from non-coding RNAs (ncRNAs) to …

Pathogens in engineered water systems

F Huang, Y Zhao, Y Su, R Gao, W Zhang… - Water Security: Big Data …, 2024 - Elsevier
The safe reuse of reclaimed water represents a pivotal solution for overcoming challenges
associated with water scarcity and pollution. However, engineered water systems such as …