Purpose. NSAIDs constitute an important class of drugs with therapeutic applications that
have spanned several centuries. Treatment of inflammatory conditions such as rheumatoid …

Photodynamic therapy (PDT) involves the administration of a photosensitizer (PS) followed
by illumination with visible light, leading to generation of reactive oxygen species. The …

Abstract Selective COX-2 inhibitors (coxibs) are approved for the relief of acute pain and
symptoms of chronic inflammatory conditions such as osteoarthritis (OA) and rheumatoid …

PG (prostaglandin) E2 plays an important role in the modulation of the immune response
and the inflammatory process. In the present study, we describe a PGE2 positive feedback …

Eicosanoids, a family of oxygenated metabolites of eicosapolyenoic fatty acids, such as
arachidonic acid, formed via the lipoxygenase, cyclooxygenase (COX) and epoxygenase …

The most common and leading cause of cancer-related death in men is lung cancer. Despite
the recent advances in chemotherapy, advanced lung cancer still remains incurable. For …

Background Immunotherapeutic approaches have revolutionized oncological practice but
are less evaluated in gynecological malignancies. PD-1/PD-L1 blockade in gynecological …

Several studies illustrated considerably elevated levels of cyclooxygenase-2 (COX-2)
protein in various types of human cancer including malignant melanoma. Recently, it was …

Abstract Aims: The ginsenoside Rg3 (Rg3) inhibits xenograft growth and angiogenesis in
tumors mainly via down-regulates VEGF expression. This study was designed to investigate …

Different agents able to modulate apoptosis have been shown to modify the expression of
the MAP-kinase-phosphatase-1 (MKP-1). The expression of this phosphatase has been …