Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are
able to evade the immune response and establish a very complex balance in which different …

Compared with conventional chemotherapy and targeted therapy, immunotherapy has
changed the treatment prospects of various solid tumors and has recently become the main …

The chimeric antigen receptor T (CAR-T) cell therapy is a newly developed adoptive
antitumor treatment. Theoretically, CAR-T cells can specifically localize and eliminate tumor …

We generated MHC-independent chimeric antigen receptors (CARs) directed to the GD2
antigen expressed by neuroblastoma tumor cells and treated patients with this disease. Two …

The adoptive transfer of CD19-specific chimeric antigen receptor engineered T cells (CAR T
cells) resulted in encouraging clinical trials in indolent B-cell malignancies. However, they …

Harnessing the immune system to recognize and destroy tumor cells has been the central
goal of anti-cancer immunotherapy. In recent years, there has been an increased interest in …

As significant numbers of acute myeloid leukemia (AML) patients are still refractory to
conventional therapies or experience relapse, immunotherapy using T cells expressing …

Purpose: To develop an adaptable gene-based vector that will confer immune cell specificity
to various cancer types. Experimental Design: Human and mouse T cells were genetically …

We present an overview of clinical trials involving gene editing using clustered interspaced
short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9), transcription …

The Th2 cytokines, interleukin (IL)-4 and-13, are structurally and functionally related. They
regulate immune responses and the immune microenvironment, not only under normal …